The association of pattern of lifetime alcohol use and cause of death in the European prospective investigation into cancer and nutrition (EPIC) study.
BACKGROUND: There is limited evidence for an association between the pattern of lifetime alcohol use and cause-specific risk of death. METHODS: Multivariable hazard ratios were estimated for different causes of death according to patterns of lifetime alcohol consumption using a competing risks appro...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
2013
|
| _version_ | 1826284579489579008 |
|---|---|
| author | Bergmann, M Rehm, J Klipstein-Grobusch, K Boeing, H Schütze, M Drogan, D Overvad, K Tjønneland, A Halkjær, J Fagherazzi, G Boutron-Ruault, M Clavel-Chapelon, F Teucher, B Kaaks, R Trichopoulou, A Benetou, V Trichopoulos, D Palli, D Pala, V Tumino, R Vineis, P Beulens, J Redondo, M Duell, E Molina-Montes, E |
| author_facet | Bergmann, M Rehm, J Klipstein-Grobusch, K Boeing, H Schütze, M Drogan, D Overvad, K Tjønneland, A Halkjær, J Fagherazzi, G Boutron-Ruault, M Clavel-Chapelon, F Teucher, B Kaaks, R Trichopoulou, A Benetou, V Trichopoulos, D Palli, D Pala, V Tumino, R Vineis, P Beulens, J Redondo, M Duell, E Molina-Montes, E |
| author_sort | Bergmann, M |
| collection | OXFORD |
| description | BACKGROUND: There is limited evidence for an association between the pattern of lifetime alcohol use and cause-specific risk of death. METHODS: Multivariable hazard ratios were estimated for different causes of death according to patterns of lifetime alcohol consumption using a competing risks approach: 111 953 men and 268 442 women from eight countries participating in the European Prospective Investigation into Cancer and Nutrition (EPIC) study were included. Self-reported alcohol consumption at ages 20, 30, 40 or 50 years and at enrollment were used for the analysis; 26 411 deaths were observed during an average of 12.6 years of follow-up. RESULTS: The association between lifetime alcohol use and death from cardiovascular diseases was different from the association seen for alcohol-related cancers, digestive, respiratory, external and other causes. Heavy users (>5 drinks/day for men and >2.5 drinks/day for women), regardless of time of cessation, had a 2- to 5-times higher risk of dying due to alcohol-related cancers, compared with subjects with lifetime light use (≤1 and ≤0.5 drink/week for men and women, respectively). Compared with lifetime light users, men who used <5 drinks/day throughout their lifetime had a 24% lower cardiovascular disease mortality (95% confidence interval 2-41). The risk of death from coronary heart disease was also found to be 34-46% lower among women who were moderate to occasionally heavy alcohol users compared with light users. However, this relationship was only evident among men and women who had no chronic disease at enrollment. CONCLUSIONS: Limiting alcohol use throughout life is associated with a lower risk of death, largely due to cardiovascular disease but also other causes. However, the potential health benefits of alcohol use are difficult to establish due to the possibility of selection bias and competing risks related to diseases occurring later in life. |
| first_indexed | 2024-03-07T01:15:58Z |
| format | Journal article |
| id | oxford-uuid:8eaf1710-6aec-4ad8-a9b5-6731db393b4d |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T01:15:58Z |
| publishDate | 2013 |
| record_format | dspace |
| spelling | oxford-uuid:8eaf1710-6aec-4ad8-a9b5-6731db393b4d2022-03-26T22:59:24ZThe association of pattern of lifetime alcohol use and cause of death in the European prospective investigation into cancer and nutrition (EPIC) study.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:8eaf1710-6aec-4ad8-a9b5-6731db393b4dEnglishSymplectic Elements at Oxford2013Bergmann, MRehm, JKlipstein-Grobusch, KBoeing, HSchütze, MDrogan, DOvervad, KTjønneland, AHalkjær, JFagherazzi, GBoutron-Ruault, MClavel-Chapelon, FTeucher, BKaaks, RTrichopoulou, ABenetou, VTrichopoulos, DPalli, DPala, VTumino, RVineis, PBeulens, JRedondo, MDuell, EMolina-Montes, EBACKGROUND: There is limited evidence for an association between the pattern of lifetime alcohol use and cause-specific risk of death. METHODS: Multivariable hazard ratios were estimated for different causes of death according to patterns of lifetime alcohol consumption using a competing risks approach: 111 953 men and 268 442 women from eight countries participating in the European Prospective Investigation into Cancer and Nutrition (EPIC) study were included. Self-reported alcohol consumption at ages 20, 30, 40 or 50 years and at enrollment were used for the analysis; 26 411 deaths were observed during an average of 12.6 years of follow-up. RESULTS: The association between lifetime alcohol use and death from cardiovascular diseases was different from the association seen for alcohol-related cancers, digestive, respiratory, external and other causes. Heavy users (>5 drinks/day for men and >2.5 drinks/day for women), regardless of time of cessation, had a 2- to 5-times higher risk of dying due to alcohol-related cancers, compared with subjects with lifetime light use (≤1 and ≤0.5 drink/week for men and women, respectively). Compared with lifetime light users, men who used <5 drinks/day throughout their lifetime had a 24% lower cardiovascular disease mortality (95% confidence interval 2-41). The risk of death from coronary heart disease was also found to be 34-46% lower among women who were moderate to occasionally heavy alcohol users compared with light users. However, this relationship was only evident among men and women who had no chronic disease at enrollment. CONCLUSIONS: Limiting alcohol use throughout life is associated with a lower risk of death, largely due to cardiovascular disease but also other causes. However, the potential health benefits of alcohol use are difficult to establish due to the possibility of selection bias and competing risks related to diseases occurring later in life. |
| spellingShingle | Bergmann, M Rehm, J Klipstein-Grobusch, K Boeing, H Schütze, M Drogan, D Overvad, K Tjønneland, A Halkjær, J Fagherazzi, G Boutron-Ruault, M Clavel-Chapelon, F Teucher, B Kaaks, R Trichopoulou, A Benetou, V Trichopoulos, D Palli, D Pala, V Tumino, R Vineis, P Beulens, J Redondo, M Duell, E Molina-Montes, E The association of pattern of lifetime alcohol use and cause of death in the European prospective investigation into cancer and nutrition (EPIC) study. |
| title | The association of pattern of lifetime alcohol use and cause of death in the European prospective investigation into cancer and nutrition (EPIC) study. |
| title_full | The association of pattern of lifetime alcohol use and cause of death in the European prospective investigation into cancer and nutrition (EPIC) study. |
| title_fullStr | The association of pattern of lifetime alcohol use and cause of death in the European prospective investigation into cancer and nutrition (EPIC) study. |
| title_full_unstemmed | The association of pattern of lifetime alcohol use and cause of death in the European prospective investigation into cancer and nutrition (EPIC) study. |
| title_short | The association of pattern of lifetime alcohol use and cause of death in the European prospective investigation into cancer and nutrition (EPIC) study. |
| title_sort | association of pattern of lifetime alcohol use and cause of death in the european prospective investigation into cancer and nutrition epic study |
| work_keys_str_mv | AT bergmannm theassociationofpatternoflifetimealcoholuseandcauseofdeathintheeuropeanprospectiveinvestigationintocancerandnutritionepicstudy AT rehmj theassociationofpatternoflifetimealcoholuseandcauseofdeathintheeuropeanprospectiveinvestigationintocancerandnutritionepicstudy AT klipsteingrobuschk theassociationofpatternoflifetimealcoholuseandcauseofdeathintheeuropeanprospectiveinvestigationintocancerandnutritionepicstudy AT boeingh theassociationofpatternoflifetimealcoholuseandcauseofdeathintheeuropeanprospectiveinvestigationintocancerandnutritionepicstudy AT schutzem theassociationofpatternoflifetimealcoholuseandcauseofdeathintheeuropeanprospectiveinvestigationintocancerandnutritionepicstudy AT drogand theassociationofpatternoflifetimealcoholuseandcauseofdeathintheeuropeanprospectiveinvestigationintocancerandnutritionepicstudy AT overvadk theassociationofpatternoflifetimealcoholuseandcauseofdeathintheeuropeanprospectiveinvestigationintocancerandnutritionepicstudy AT tjønnelanda theassociationofpatternoflifetimealcoholuseandcauseofdeathintheeuropeanprospectiveinvestigationintocancerandnutritionepicstudy AT halkjærj theassociationofpatternoflifetimealcoholuseandcauseofdeathintheeuropeanprospectiveinvestigationintocancerandnutritionepicstudy AT fagherazzig theassociationofpatternoflifetimealcoholuseandcauseofdeathintheeuropeanprospectiveinvestigationintocancerandnutritionepicstudy AT boutronruaultm theassociationofpatternoflifetimealcoholuseandcauseofdeathintheeuropeanprospectiveinvestigationintocancerandnutritionepicstudy AT clavelchapelonf theassociationofpatternoflifetimealcoholuseandcauseofdeathintheeuropeanprospectiveinvestigationintocancerandnutritionepicstudy AT teucherb theassociationofpatternoflifetimealcoholuseandcauseofdeathintheeuropeanprospectiveinvestigationintocancerandnutritionepicstudy AT kaaksr theassociationofpatternoflifetimealcoholuseandcauseofdeathintheeuropeanprospectiveinvestigationintocancerandnutritionepicstudy AT trichopouloua theassociationofpatternoflifetimealcoholuseandcauseofdeathintheeuropeanprospectiveinvestigationintocancerandnutritionepicstudy AT benetouv theassociationofpatternoflifetimealcoholuseandcauseofdeathintheeuropeanprospectiveinvestigationintocancerandnutritionepicstudy AT trichopoulosd theassociationofpatternoflifetimealcoholuseandcauseofdeathintheeuropeanprospectiveinvestigationintocancerandnutritionepicstudy AT pallid theassociationofpatternoflifetimealcoholuseandcauseofdeathintheeuropeanprospectiveinvestigationintocancerandnutritionepicstudy AT palav theassociationofpatternoflifetimealcoholuseandcauseofdeathintheeuropeanprospectiveinvestigationintocancerandnutritionepicstudy AT tuminor theassociationofpatternoflifetimealcoholuseandcauseofdeathintheeuropeanprospectiveinvestigationintocancerandnutritionepicstudy AT vineisp theassociationofpatternoflifetimealcoholuseandcauseofdeathintheeuropeanprospectiveinvestigationintocancerandnutritionepicstudy AT beulensj theassociationofpatternoflifetimealcoholuseandcauseofdeathintheeuropeanprospectiveinvestigationintocancerandnutritionepicstudy AT redondom theassociationofpatternoflifetimealcoholuseandcauseofdeathintheeuropeanprospectiveinvestigationintocancerandnutritionepicstudy AT duelle theassociationofpatternoflifetimealcoholuseandcauseofdeathintheeuropeanprospectiveinvestigationintocancerandnutritionepicstudy AT molinamontese theassociationofpatternoflifetimealcoholuseandcauseofdeathintheeuropeanprospectiveinvestigationintocancerandnutritionepicstudy AT bergmannm associationofpatternoflifetimealcoholuseandcauseofdeathintheeuropeanprospectiveinvestigationintocancerandnutritionepicstudy AT rehmj associationofpatternoflifetimealcoholuseandcauseofdeathintheeuropeanprospectiveinvestigationintocancerandnutritionepicstudy AT klipsteingrobuschk associationofpatternoflifetimealcoholuseandcauseofdeathintheeuropeanprospectiveinvestigationintocancerandnutritionepicstudy AT boeingh associationofpatternoflifetimealcoholuseandcauseofdeathintheeuropeanprospectiveinvestigationintocancerandnutritionepicstudy AT schutzem associationofpatternoflifetimealcoholuseandcauseofdeathintheeuropeanprospectiveinvestigationintocancerandnutritionepicstudy AT drogand associationofpatternoflifetimealcoholuseandcauseofdeathintheeuropeanprospectiveinvestigationintocancerandnutritionepicstudy AT overvadk associationofpatternoflifetimealcoholuseandcauseofdeathintheeuropeanprospectiveinvestigationintocancerandnutritionepicstudy AT tjønnelanda associationofpatternoflifetimealcoholuseandcauseofdeathintheeuropeanprospectiveinvestigationintocancerandnutritionepicstudy AT halkjærj associationofpatternoflifetimealcoholuseandcauseofdeathintheeuropeanprospectiveinvestigationintocancerandnutritionepicstudy AT fagherazzig associationofpatternoflifetimealcoholuseandcauseofdeathintheeuropeanprospectiveinvestigationintocancerandnutritionepicstudy AT boutronruaultm associationofpatternoflifetimealcoholuseandcauseofdeathintheeuropeanprospectiveinvestigationintocancerandnutritionepicstudy AT clavelchapelonf associationofpatternoflifetimealcoholuseandcauseofdeathintheeuropeanprospectiveinvestigationintocancerandnutritionepicstudy AT teucherb associationofpatternoflifetimealcoholuseandcauseofdeathintheeuropeanprospectiveinvestigationintocancerandnutritionepicstudy AT kaaksr associationofpatternoflifetimealcoholuseandcauseofdeathintheeuropeanprospectiveinvestigationintocancerandnutritionepicstudy AT trichopouloua associationofpatternoflifetimealcoholuseandcauseofdeathintheeuropeanprospectiveinvestigationintocancerandnutritionepicstudy AT benetouv associationofpatternoflifetimealcoholuseandcauseofdeathintheeuropeanprospectiveinvestigationintocancerandnutritionepicstudy AT trichopoulosd associationofpatternoflifetimealcoholuseandcauseofdeathintheeuropeanprospectiveinvestigationintocancerandnutritionepicstudy AT pallid associationofpatternoflifetimealcoholuseandcauseofdeathintheeuropeanprospectiveinvestigationintocancerandnutritionepicstudy AT palav associationofpatternoflifetimealcoholuseandcauseofdeathintheeuropeanprospectiveinvestigationintocancerandnutritionepicstudy AT tuminor associationofpatternoflifetimealcoholuseandcauseofdeathintheeuropeanprospectiveinvestigationintocancerandnutritionepicstudy AT vineisp associationofpatternoflifetimealcoholuseandcauseofdeathintheeuropeanprospectiveinvestigationintocancerandnutritionepicstudy AT beulensj associationofpatternoflifetimealcoholuseandcauseofdeathintheeuropeanprospectiveinvestigationintocancerandnutritionepicstudy AT redondom associationofpatternoflifetimealcoholuseandcauseofdeathintheeuropeanprospectiveinvestigationintocancerandnutritionepicstudy AT duelle associationofpatternoflifetimealcoholuseandcauseofdeathintheeuropeanprospectiveinvestigationintocancerandnutritionepicstudy AT molinamontese associationofpatternoflifetimealcoholuseandcauseofdeathintheeuropeanprospectiveinvestigationintocancerandnutritionepicstudy |