Homodimerisation of the lymph vessel endothelial receptor LYVE-1 through a redox-labile disulfide is critical for hyaluronan binding in lymphatic endothelium

The lymphatic vessel endothelial receptor LYVE-1 is implicated in uptake of hyaluronan (HA) and trafficking of leucocytes to draining lymph nodes. Yet LYVE-1 has only weak affinity for hyaluronan, and depends on receptor clustering and higher-order ligand organisation for durable binding in lymphati...

Szczegółowa specyfikacja

Opis bibliograficzny
Główni autorzy: Banerji, S, Lawrance, W, Metcalfe, C, Briggs, D, Yamauchi, A, Dushek, O, Van der Merwe, P, Day, A, Jackson, D
Format: Journal article
Wydane: American Society for Biochemistry and Molecular Biology 2016