A naturally occurring variant in human TLR9, P99L, is associated with loss of CpG oligonucleotide responsiveness.

A naturally occurring variant in human TLR9, P99L, is associated with loss of CpG oligonucleotide responsiveness.

The innate immune system employs Toll-like receptors (TLRs) for the detection of invading microorganisms based on distinct molecular patterns. For example, TLR9 is activated by microbial DNA and also by short therapeutic CpG-containing oligonucleotides (CpG-ODN). TLR9 activation leads to the product...

Podrobná bibliografie
Hlavní autoři:	Kubarenko, A, Ranjan, S, Rautanen, A, Mills, T, Wong, S, Vannberg, F, Neumaier, M, Bekeredjian-Ding, I, Hill, A, Ahmad-Nejad, P, Weber, A
Médium:	Journal article
Jazyk:	English
Vydáno:	2010

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