A naturally occurring variant in human TLR9, P99L, is associated with loss of CpG oligonucleotide responsiveness.
The innate immune system employs Toll-like receptors (TLRs) for the detection of invading microorganisms based on distinct molecular patterns. For example, TLR9 is activated by microbial DNA and also by short therapeutic CpG-containing oligonucleotides (CpG-ODN). TLR9 activation leads to the product...
| Autors principals: | , , , , , , , , , , |
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| Format: | Journal article |
| Idioma: | English |
| Publicat: |
2010
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