The importance of hypoxia in radiotherapy for the immune response, metastatic potential and FLASH-RT
<strong>Purpose: </strong>Hypoxia (low oxygen) is a common feature of solid tumours that has been intensely studied for more than six decades. Here we review the importance of hypoxia to radiotherapy with a particular focus on the contribution of hypoxia to immune responses, metastatic p...
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| Format: | Journal article |
| Idioma: | English |
| Publicat: |
Taylor and Francis
2021
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| Sumari: | <strong>Purpose: </strong>Hypoxia (low oxygen) is a common feature of solid tumours that has been intensely studied for more than six decades. Here we review the importance of hypoxia to radiotherapy with a particular focus on the contribution of hypoxia to immune responses, metastatic potential and FLASH radiotherapy, active areas of research by leading women in the field.
<br><strong>Conclusion: </strong>Although hypoxia-driven metastasis and immunosuppression can negatively impact clinical outcome, understanding these processes can also provide tumour-specific vulnerabilities that may be therapeutically exploited. The different oxygen tensions present in tumours and normal tissues may underpin the beneficial FLASH sparing effect seen in normal tissue and represents a perfect example of advances in the field that can leverage tumour hypoxia to improve future radiotherapy treatments. |
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