Fine-mapping the HOXB region detects common variants tagging a rare coding allele: evidence for synthetic association in prostate cancer

The HOXB13 gene has been implicated in prostate cancer (PrCa) susceptibility. We performed a high resolution fine-mapping analysis to comprehensively evaluate the association between common genetic variation across the HOXB genetic locus at 17q21 and PrCa risk. This involved genotyping 700 SNPs usin...

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Main Authors:	Saunders, E, Dadaev, T, Leongamornlert, D, Jugurnauth-Little, S, Tymrakiewicz, M, Wiklund, F, Al Olama, A, Benlloch, S, Neal, D, Hamdy, F, Donovan, J, Giles, G, Severi, G, Gronberg, H, Aly, M, Haiman, C, Schumacher, F, Henderson, B, Lindstrom, S, Kraft, P, Hunter, D, Gapstur, S, Chanock, S, Berndt, S, Albanes, D, Andriole, G, Schleutker, J, Weischer, M, Nordestgaard, BG, Canzian, F, Campa, D, Riboli, E, Key, T, Travis, R, Ingles, SA, John, E, Hayes, R, Pharoah, P, Khaw, K, Stanford, J, Ostrander, E, Signorello, L, Thibodeau, SN, Schaid, D, Maier, C, Kibel, A, Cybulski, C, Cannon-Albright, L, Brenner, H, Park, J, Kaneva, R, Batra, J, Clements, J, Teixeira, MR, Xu, J, Mikropoulos, C, Goh, C, Govindasami, K, Guy, M, Wilkinson, R, Sawyer, E, Morgan, A, Easton, D, Muir, K, Eeles, R, Kote-Jarai, Z
Format:	Journal article
Language:	English
Published:	Public Library of Science 2014

Fine-mapping the HOXB region detects common variants tagging a rare coding allele: evidence for synthetic association in prostate cancer

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