Compartmentalizing acid stress in bacteria
A Donnan equilibrium causes an influx of chloride ions into the Escherichia coli periplasm when the bacterium finds itself in gastric fluid. The combination of low pH and high anion concentration drives proteins to aggregate, a potentially lethal event unless prevented by specific chaperones.
| Main Author: | |
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| Format: | Journal article |
| Language: | English |
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Nature Publishing Group
2018
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| _version_ | 1797081606284902400 |
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| author | Kleanthous, C |
| author_facet | Kleanthous, C |
| author_sort | Kleanthous, C |
| collection | OXFORD |
| description | A Donnan equilibrium causes an influx of chloride ions into the Escherichia coli periplasm when the bacterium finds itself in gastric fluid. The combination of low pH and high anion concentration drives proteins to aggregate, a potentially lethal event unless prevented by specific chaperones. |
| first_indexed | 2024-03-07T01:16:35Z |
| format | Journal article |
| id | oxford-uuid:8ee44655-c3ab-4f8e-a8dd-e670515c848b |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T01:16:35Z |
| publishDate | 2018 |
| publisher | Nature Publishing Group |
| record_format | dspace |
| spelling | oxford-uuid:8ee44655-c3ab-4f8e-a8dd-e670515c848b2022-03-26T23:00:39ZCompartmentalizing acid stress in bacteriaJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:8ee44655-c3ab-4f8e-a8dd-e670515c848bEnglishSymplectic Elements at OxfordNature Publishing Group2018Kleanthous, CA Donnan equilibrium causes an influx of chloride ions into the Escherichia coli periplasm when the bacterium finds itself in gastric fluid. The combination of low pH and high anion concentration drives proteins to aggregate, a potentially lethal event unless prevented by specific chaperones. |
| spellingShingle | Kleanthous, C Compartmentalizing acid stress in bacteria |
| title | Compartmentalizing acid stress in bacteria |
| title_full | Compartmentalizing acid stress in bacteria |
| title_fullStr | Compartmentalizing acid stress in bacteria |
| title_full_unstemmed | Compartmentalizing acid stress in bacteria |
| title_short | Compartmentalizing acid stress in bacteria |
| title_sort | compartmentalizing acid stress in bacteria |
| work_keys_str_mv | AT kleanthousc compartmentalizingacidstressinbacteria |