2,5-Disubstituted pyrrolidines: versatile regioselective and diastereoselective synthesis by enamine reduction and subsequent alkylation.

2,5-Disubstituted pyrrolidines: versatile regioselective and diastereoselective synthesis by enamine reduction and subsequent alkylation.

A direct and versatile route enabling the regio- and diastereoselective synthesis of 2,5-disubstituted pyrrolidines by reduction of enamines derived from pyroglutamic acid is reported.

Библиографические подробности
Главные авторы:	Hussaini, SR, Moloney, M
Формат:	Journal article
Язык:	English
Опубликовано:	2003

Схожие документы

2,5-Disubstituted pyrrolidines: synthesis by enamine reduction and subsequent regioselective and diastereoselective alkylations.
по: Hussaini, SR, и др.
Опубликовано: (2006)

cis-Selective synthesis of 2,5-disubstituted pyrrolidines
по: Hussaini, SR, и др.
Опубликовано: (2004)

Enantioenriched a-substituted aldehydes via diastereoselective enamine alkylation
по: Kaka, N, и др.
Опубликовано: (2007)

Stereoselectivity in the double reductive alkylation of pyrroles: synthesis of cis-3,4-disubstituted pyrrolidines
по: Donohoe, T, и др.
Опубликовано: (1999)

Regioselective reduction of beta-enaminoesters
по: Hussaini, SR, и др.
Опубликовано: (2005)

trans-2,5-Disubstituted pyrrolidines: Rapid stereocontrolled access from sulfones.
по: Moloney, M, и др.
Опубликовано: (2006)

Diastereoselectivity in the alkylations of bicyclic piperidinones
по: Mills, C, и др.
Опубликовано: (1998)

On the diastereoselectivity of alkylations of bicyclic lactams
по: Bailey, J, и др.
Опубликовано: (2000)

Synthesis and C-alkylation of hindered aldehyde enamines.
по: Hodgson, D, и др.
Опубликовано: (2009)

Interception of enamine intermediates in reductive functionalization of lactams by sodium hydride: synthesis of 2-cyano-3-iodo piperidines and pyrrolidines
по: Chen, Jiahua, и др.
Опубликовано: (2022)

A New and Efficient Method for the Synthesis of 3,4-Disubstituted Pyrrolidine-2,5-diones
по: Rositca D. Nikolova, и др.
Опубликовано: (2012-04-01)

Asymmetric synthesis of α-alkylated aldehydes using chiral enamines
по: Kaka, N, и др.
Опубликовано: (2008)

Stereoselective reductive alkylation of 2,5-disubstituted pyrroles: a role for naphthalene in the partial reduction of heterocycles
по: Donohoe, T, и др.
Опубликовано: (2000)

Facile Access to Unnatural Dipeptide-Alcohols Based on cis-2,5-Disubstituted Pyrrolidines
по: Yan-Yan Jia, и др.
Опубликовано: (2015-02-01)

C-alkylation of chiral tropane- and homotropane-derived enamines.
по: Hodgson, D, и др.
Опубликовано: (2013)

On the origins of diastereoselectivity in the alkylation of diketopiperazine enolates
по: Bull, S, и др.
Опубликовано: (2007)

Alkyl halides as both hydride and alkyl sources in catalytic regioselective reductive olefin hydroalkylation
по: Xianxiao Chen, и др.
Опубликовано: (2020-11-01)

Facile, Regio- and Diastereoselective Synthesis of Spiro-Pyrrolidine and Pyrrolizine Derivatives and Evaluation of Their Antiproliferative Activities
по: Almansour, Abdulrahman I., и др.
Опубликовано: (2014)

A Diastereoselective Synthesis of Dispiro[oxindole-cyclohexanone]pyrrolidines by 1,3-Dipolar Cycloaddition
по: Alexander Anis’kov, и др.
Опубликовано: (2017-12-01)

Facile, Regio- and Diastereoselective Synthesis of Spiro-Pyrrolidine and Pyrrolizine Derivatives and Evaluation of Their Antiproliferative Activities
по: Abdulrahman I. Almansour, и др.
Опубликовано: (2014-07-01)

Enantio- and diastereoselective catalytic alkylation reactions with aziridines.
по: Moss, T, и др.
Опубликовано: (2008)

Catalytic enantio- and diastereoselective alkylations with cyclic sulfamidates.
по: Moss, T, и др.
Опубликовано: (2010)

Enantioselective biocatalytic desymmetrization for synthesis of enantiopure cis-3,4-disubstituted pyrrolidines
по: Hui-Juan Hu, и др.
Опубликовано: (2021-08-01)

Asymmetric synthesis of alpha-alkylated aldehydes using terminal epoxide-derived chiral enamines.
по: Hodgson, D, и др.
Опубликовано: (2008)

Regioselective alkylation of a versatile indazole: Electrophile scope and mechanistic insights from density functional theory calculations
по: Pengcheng Lu, и др.
Опубликовано: (2024-08-01)

Regioselective Ni-Catalyzed reductive alkylsilylation of acrylonitrile with unactivated alkyl bromides and chlorosilanes
по: Jinwei Sun, и др.
Опубликовано: (2022-11-01)

Regioselective synthesis of C3 alkylated and arylated benzothiophenes
по: Harry J. Shrives, и др.
Опубликовано: (2017-03-01)

Diastereoselective reduction of the tricarbonyl moiety in bicyclic tetramates giving pyroglutamates
по: Josa-Culleré, L, и др.
Опубликовано: (2018)

Asymmetric Induction in C-Alkylation of Tropane-Derived Enamines: Congruence Between Computation and Experiment
по: Li, Y, и др.
Опубликовано: (2017)

One-pot tandem cyclization of enantiopure asymmetric cis-2,5-disubstituted pyrrolidines: Facile access to chiral 10-heteroazatriquinanes
по: Ping-An Wang, и др.
Опубликовано: (2013-02-01)

Regioselective Alkylation of an Oxonaphthalene-Annelated Pyrrol System
по: Helmut Spreitzer, и др.
Опубликовано: (2009-09-01)

Enamine Compounds /
по: Deyoung, Gwyn, author 648433
Опубликовано: (2012)

The hydroboration of enamines
по: Christian T. Goralski, и др.
Опубликовано: (2012-07-01)

Pyrrolidine-2,5-dione
по: Min Yu, и др.
Опубликовано: (2012-09-01)

Flexibility in the partial reduction of 2,5-disubstituted pyrroles: application to the synthesis of DMDP.
по: Donohoe, T, и др.
Опубликовано: (2003)

Studies with enamines: Functionally substituted enamines as aldehyde equivalents in Gewald reaction
по: Saleh Al-Mousawi, и др.
Опубликовано: (2007-11-01)

Regioselective copper-catalyzed oxidative coupling of α-alkylated styrenes with tertiary alkyl radicals
по: Wang, Cong, и др.
Опубликовано: (2020)

Transition states and origins of 1,4-asymmetric induction in alkylations of 2,2,6-trialkylpiperidine enamines.
по: Um, J, и др.
Опубликовано: (2010)

Diastereoselective synthesis of new O-alkylated and C-branched inositols and their corresponding fluoro analogues
по: Charlotte Collet, и др.
Опубликовано: (2016-02-01)

Diastereoselective synthesis of pyrrolidine derivatives via a one-pot nitro-Mannich/hydroamination cascade using base and gold catalysis.
по: Ďuriš, A, и др.
Опубликовано: (2013)