Endogenous sex steroids and risk of cervical carcinoma: results from the EPIC study.
BACKGROUND: Epidemiologic data and animal models suggest that, despite the predominant role of human papillomavirus infection, sex steroid hormones are also involved in the etiology of invasive cervical carcinoma (ICC). METHODS: Ninety-nine ICC cases, 121 cervical intraepithelial neoplasia grade 3 (...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
2011
|
| _version_ | 1797081626023297024 |
|---|---|
| author | Rinaldi, S Plummer, M Biessy, C Castellsagué, X Overvad, K Krüger Kjær, S Tjønneland, A Clavel-Chapelon, F Chabbert-Buffet, N Mesrine, S Lukanova, A Kaaks, R Weikert, C Boeing, H Trichopoulou, A Lagiou, P Trichopoulos, D Palli, D Agnoli, C Tumino, R Vineis, P Panico, S Bueno-de-Mesquita, B van Kranen, H Peeters, P |
| author_facet | Rinaldi, S Plummer, M Biessy, C Castellsagué, X Overvad, K Krüger Kjær, S Tjønneland, A Clavel-Chapelon, F Chabbert-Buffet, N Mesrine, S Lukanova, A Kaaks, R Weikert, C Boeing, H Trichopoulou, A Lagiou, P Trichopoulos, D Palli, D Agnoli, C Tumino, R Vineis, P Panico, S Bueno-de-Mesquita, B van Kranen, H Peeters, P |
| author_sort | Rinaldi, S |
| collection | OXFORD |
| description | BACKGROUND: Epidemiologic data and animal models suggest that, despite the predominant role of human papillomavirus infection, sex steroid hormones are also involved in the etiology of invasive cervical carcinoma (ICC). METHODS: Ninety-nine ICC cases, 121 cervical intraepithelial neoplasia grade 3 (CIN3) cases and 2 control women matched with each case for center, age, menopausal status and blood collection-related variables, were identified in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Circulating levels of testosterone (T) and estradiol (E(2)); dehydroepiandrosterone sulfate (DHEAS); progesterone (premenopausal women); and sex hormone-binding globulin (SHBG) were measured using immunoassays. Levels of free (f) T and E(2) were calculated from absolute concentrations of T, E(2), and SHBG. Odds ratios (ORs) and 95% confidence intervals (CI) were computed using regularized conditional logistic regression. RESULTS: Among premenopausal women, associations with ICC were observed for fT (OR for highest vs. lowest tertile = 5.16, 95% CI, 1.50-20.1). SHBG level was associated with a significant downward trend in ICC risk. T, E(2), fE(2), and DHEAS showed nonsignificant positive association with ICC. Progesterone was uninfluential. Among postmenopausal women, associations with ICC were found for T (OR = 3.14; 95% CI, 1.21-9.37), whereas E(2) and fT showed nonsignificant positive association. SHBG level was unrelated to ICC risk in postmenopausal women. No associations between any hormone and CIN3 were detected in either pre- or postmenopausal women. CONCLUSIONS: Our findings suggest for the first time that T and possibly E(2) may be involved in the etiology of ICC. IMPACT: The responsiveness of cervical tumors to hormone modulators is worth exploring. |
| first_indexed | 2024-03-07T01:16:49Z |
| format | Journal article |
| id | oxford-uuid:8ef850c6-690d-4fcc-9e51-78c2142c142e |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T01:16:49Z |
| publishDate | 2011 |
| record_format | dspace |
| spelling | oxford-uuid:8ef850c6-690d-4fcc-9e51-78c2142c142e2022-03-26T23:01:14ZEndogenous sex steroids and risk of cervical carcinoma: results from the EPIC study.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:8ef850c6-690d-4fcc-9e51-78c2142c142eEnglishSymplectic Elements at Oxford2011Rinaldi, SPlummer, MBiessy, CCastellsagué, XOvervad, KKrüger Kjær, STjønneland, AClavel-Chapelon, FChabbert-Buffet, NMesrine, SLukanova, AKaaks, RWeikert, CBoeing, HTrichopoulou, ALagiou, PTrichopoulos, DPalli, DAgnoli, CTumino, RVineis, PPanico, SBueno-de-Mesquita, Bvan Kranen, HPeeters, PBACKGROUND: Epidemiologic data and animal models suggest that, despite the predominant role of human papillomavirus infection, sex steroid hormones are also involved in the etiology of invasive cervical carcinoma (ICC). METHODS: Ninety-nine ICC cases, 121 cervical intraepithelial neoplasia grade 3 (CIN3) cases and 2 control women matched with each case for center, age, menopausal status and blood collection-related variables, were identified in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Circulating levels of testosterone (T) and estradiol (E(2)); dehydroepiandrosterone sulfate (DHEAS); progesterone (premenopausal women); and sex hormone-binding globulin (SHBG) were measured using immunoassays. Levels of free (f) T and E(2) were calculated from absolute concentrations of T, E(2), and SHBG. Odds ratios (ORs) and 95% confidence intervals (CI) were computed using regularized conditional logistic regression. RESULTS: Among premenopausal women, associations with ICC were observed for fT (OR for highest vs. lowest tertile = 5.16, 95% CI, 1.50-20.1). SHBG level was associated with a significant downward trend in ICC risk. T, E(2), fE(2), and DHEAS showed nonsignificant positive association with ICC. Progesterone was uninfluential. Among postmenopausal women, associations with ICC were found for T (OR = 3.14; 95% CI, 1.21-9.37), whereas E(2) and fT showed nonsignificant positive association. SHBG level was unrelated to ICC risk in postmenopausal women. No associations between any hormone and CIN3 were detected in either pre- or postmenopausal women. CONCLUSIONS: Our findings suggest for the first time that T and possibly E(2) may be involved in the etiology of ICC. IMPACT: The responsiveness of cervical tumors to hormone modulators is worth exploring. |
| spellingShingle | Rinaldi, S Plummer, M Biessy, C Castellsagué, X Overvad, K Krüger Kjær, S Tjønneland, A Clavel-Chapelon, F Chabbert-Buffet, N Mesrine, S Lukanova, A Kaaks, R Weikert, C Boeing, H Trichopoulou, A Lagiou, P Trichopoulos, D Palli, D Agnoli, C Tumino, R Vineis, P Panico, S Bueno-de-Mesquita, B van Kranen, H Peeters, P Endogenous sex steroids and risk of cervical carcinoma: results from the EPIC study. |
| title | Endogenous sex steroids and risk of cervical carcinoma: results from the EPIC study. |
| title_full | Endogenous sex steroids and risk of cervical carcinoma: results from the EPIC study. |
| title_fullStr | Endogenous sex steroids and risk of cervical carcinoma: results from the EPIC study. |
| title_full_unstemmed | Endogenous sex steroids and risk of cervical carcinoma: results from the EPIC study. |
| title_short | Endogenous sex steroids and risk of cervical carcinoma: results from the EPIC study. |
| title_sort | endogenous sex steroids and risk of cervical carcinoma results from the epic study |
| work_keys_str_mv | AT rinaldis endogenoussexsteroidsandriskofcervicalcarcinomaresultsfromtheepicstudy AT plummerm endogenoussexsteroidsandriskofcervicalcarcinomaresultsfromtheepicstudy AT biessyc endogenoussexsteroidsandriskofcervicalcarcinomaresultsfromtheepicstudy AT castellsaguex endogenoussexsteroidsandriskofcervicalcarcinomaresultsfromtheepicstudy AT overvadk endogenoussexsteroidsandriskofcervicalcarcinomaresultsfromtheepicstudy AT krugerkjærs endogenoussexsteroidsandriskofcervicalcarcinomaresultsfromtheepicstudy AT tjønnelanda endogenoussexsteroidsandriskofcervicalcarcinomaresultsfromtheepicstudy AT clavelchapelonf endogenoussexsteroidsandriskofcervicalcarcinomaresultsfromtheepicstudy AT chabbertbuffetn endogenoussexsteroidsandriskofcervicalcarcinomaresultsfromtheepicstudy AT mesrines endogenoussexsteroidsandriskofcervicalcarcinomaresultsfromtheepicstudy AT lukanovaa endogenoussexsteroidsandriskofcervicalcarcinomaresultsfromtheepicstudy AT kaaksr endogenoussexsteroidsandriskofcervicalcarcinomaresultsfromtheepicstudy AT weikertc endogenoussexsteroidsandriskofcervicalcarcinomaresultsfromtheepicstudy AT boeingh endogenoussexsteroidsandriskofcervicalcarcinomaresultsfromtheepicstudy AT trichopouloua endogenoussexsteroidsandriskofcervicalcarcinomaresultsfromtheepicstudy AT lagioup endogenoussexsteroidsandriskofcervicalcarcinomaresultsfromtheepicstudy AT trichopoulosd endogenoussexsteroidsandriskofcervicalcarcinomaresultsfromtheepicstudy AT pallid endogenoussexsteroidsandriskofcervicalcarcinomaresultsfromtheepicstudy AT agnolic endogenoussexsteroidsandriskofcervicalcarcinomaresultsfromtheepicstudy AT tuminor endogenoussexsteroidsandriskofcervicalcarcinomaresultsfromtheepicstudy AT vineisp endogenoussexsteroidsandriskofcervicalcarcinomaresultsfromtheepicstudy AT panicos endogenoussexsteroidsandriskofcervicalcarcinomaresultsfromtheepicstudy AT buenodemesquitab endogenoussexsteroidsandriskofcervicalcarcinomaresultsfromtheepicstudy AT vankranenh endogenoussexsteroidsandriskofcervicalcarcinomaresultsfromtheepicstudy AT peetersp endogenoussexsteroidsandriskofcervicalcarcinomaresultsfromtheepicstudy |