Haplotype association between haptoglobin (Hp2) and Hp promoter SNP (A-61C) may explain previous controversy of haptoglobin and malaria protection
Background: Malaria is one of the strongest recent selective pressures on the human genome, as evidenced by the high levels of varying haemoglobinopathies in human populations - despite the increased risk of mortality in the homozygous states. Previously, functional polymorphisms of Hp, coded by the...
Main Authors: | Cox, S, Doherty, C, Atkinson, S, Nweneka, C, Fulford, A, Ghattas, H, Rockett, K, Kwiatkowski, D, Prentice, A |
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Format: | Journal article |
Language: | English |
Published: |
Public Library of Science
2007
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Subjects: |
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