Adrenomedullin inhibits hypoxic cell death by upregulation of Bcl-2 in endometrial cancer cells: a possible promotion mechanism for tumour growth.
Regions of hypoxia are a common feature of solid tumours. When tumour cells are exposed to hypoxic stress, transcription of a battery of genes is initiated. The angiogenic factor adrenomedullin (ADM) is a hypoxia regulated gene. ADM is thought to act through the G protein-coupled receptor calcitonin...
Үндсэн зохиолчид: | Oehler, M, Norbury, C, Hague, S, Rees, M, Bicknell, R |
---|---|
Формат: | Journal article |
Хэл сонгох: | English |
Хэвлэсэн: |
2001
|
Ижил төстэй зүйлс
Ижил төстэй зүйлс
-
Interleukin-10 rescues T cells from apoptotic cell death: association with an upregulation of Bcl-2.
-н: Cohen, S, зэрэг
Хэвлэсэн: (1997) -
The G-protein-coupled receptor CLR is upregulated in an autocrine loop with adrenomedullin in clear cell renal cell carcinoma and associated with poor prognosis.
-н: Nikitenko, L, зэрэг
Хэвлэсэн: (2013) -
Adrenomedullin: multiple functions in human pregnancy.
-н: Wilson, C, зэрэг
Хэвлэсэн: (2004) -
Quantification of adrenomedullin transcription and expression throughout pregnancy.
-н: Wilson, C, зэрэг
Хэвлэсэн: (2005) -
Targeting the hypoxic tumour phenotype with T-cell immunotherapy
-н: Chong, T
Хэвлэсэн: (2004)