Cysteinyl leukotriene E4 activates human ILC2s and enhances the effect of prostaglandin D2 and epithelial cytokines

Cysteinyl leukotriene E4 activates human ILC2s and enhances the effect of prostaglandin D2 and epithelial cytokines

<strong>Background:</strong> Group 2 innate lymphoid cells (ILC2) are a potential innate source of type-2 cytokines in the pathogenesis of allergic conditions. Epithelial cytokines (IL-33, IL-25 and TSLP) and mast cell mediators (PGD2) are critical activators of ILC2s. Cysteinyl leukot...

Full description

Bibliographic Details
Main Authors:	Salimi, M, Stoeger, L, Liu, W, Go, S, Pavord, I, Klenerman, P, Ogg, G, Xue, L
Format:	Journal article
Published:	Elsevier 2017

Similar Items

Cysteinyl Leukotriene Pathway and Cancer
by: Ming-Ju Tsai, et al.
Published: (2021-12-01)

Leukotriene E4 activates human Th2 cells for exaggerated proinflammatory cytokine production in response to prostaglandin D2.
by: Xue, L, et al.
Published: (2012)

Cysteinyl-leukotrienes promote cutaneous Leishmaniasis control
by: Letícia Paula Trajano Noronha, et al.
Published: (2023-06-01)

Prostaglandin D2 and leukotriene E4 synergize to stimulate diverse TH2 functions and TH2 cell/neutrophil crosstalk.
by: Xue, L, et al.
Published: (2015)

Sputum cysteinyl leukotrienes increase 24 hours after allergen inhalation in atopic asthmatics.
by: Macfarlane, A, et al.
Published: (2000)

Regulation of cysteinyl leukotriene receptor 2 expression--a potential anti-tumor mechanism.
by: Cecilia Magnusson, et al.
Published: (2011-01-01)

Fevipiprant inhibits prostaglandin D2 mediated activation of group 2 innate lymphoid cells (ILC2s)
by: Sandham, D, et al.
Published: (2019)

Cysteinyl leukotriene receptor 1 is dispensable for osteoclast differentiation and bone resorption.
by: Hirofumi Fujita, et al.
Published: (2022-01-01)

Cysteinyl leukotriene type I receptor desensitization sustains Ca2+-dependent gene expression.
by: Ng, S, et al.
Published: (2012)

Fevipiprant inhibits prostaglandin D2 mediated activation of group 2 innate lymphoid cells (ILC2s)
by: Chen, W, et al.
Published: (2018)

Intercellular Ca2+ wave propagation involving positive feedback between CRAC channels and cysteinyl leukotrienes.
by: Di Capite, J, et al.
Published: (2009)

Cysteinyl leukotriene-like metabolites are generated in retinal pigment epithelial cells through glutathionylation/reduction of an oxidatively truncated fragment of arachidonate
by: Mikhail Linetsky, et al.
Published: (2023-12-01)

Involvement of 5-lipoxygenase/cysteinyl leukotriene receptor 1 in rotenone- and MPP+-induced BV2 microglial activation
by: Wang Yanfang, et al.
Published: (2012-02-01)

Inhibition of prostaglandin and leukotriene biosynthesis by gingerols and diarylheptanoids /
by: Fumiyuki Kiuchi

Cysteinyl leukotrienes as biomarkers of effect in linking exposure to air pollutants and respiratory inflammation among school children
by: Suhaimi, Nur Faseeha, et al.
Published: (2017)

Changes in histamine, HSF1, Cysteinyl leukotriene, TLR1 and TLR2 in Galleria mellonella hemolymph after Conidiobolus coronatus infection
by: J. Sobich, et al.
Published: (2023-12-01)

DNA Methylation and Gene Expression of the Cysteinyl Leukotriene Receptors as a Prognostic and Metastatic Factor for Colorectal Cancer Patients
by: Souvik Ghatak, et al.
Published: (2023-02-01)

Brain-Derived Neurotrophic Factor, Neutrophils and Cysteinyl Leukotriene Receptor 1 as Potential Prognostic Biomarkers for Patients with Colon Cancer
by: Syrina F. Mehrabi, et al.
Published: (2021-11-01)

Urinary Cysteinyl Leukotrienes as Biomarkers of Endothelial Activation, Inflammation and Oxidative Stress and Their Relationship with Organ Dysfunction in Human Septic Shock
by: Marta Reina-Couto, et al.
Published: (2022-11-01)

Methylation of cysteinyl leukotriene receptor 1 genes associates with lung function in asthmatics exposed to traffic-related air pollution
by: Nathan Rabinovitch, et al.
Published: (2021-02-01)

Prostaglandin D2 activates group 2 innate lymphoid cells through chemoattractant receptor-homologous molecule expressed on TH2 cells
by: Xue, L, et al.
Published: (2013)

Prostaglandin D2 activates group 2 innate lymphoid cells through chemoattractant receptor-homologous molecule expressed on TH2 cells.
by: Xue, L, et al.
Published: (2014)

Effects of steroids in cultured human type-2 cytokine producing cells
by: Luo, J, et al.
Published: (2018)

The Tipped Balance of ILC1/ILC2 in Peripheral Blood of Oral Lichen Planus Is Related to Inflammatory Cytokines
by: Zi-Ming Wang, et al.
Published: (2022-01-01)

Fevipiprant, a selective prostaglandin D-2 receptor 2 antagonist, potently inhibits chemotaxis and cytokine production by group 2 innate lymphoid cells
by: Xue, L, et al.
Published: (2018)

Interaction of type 2 cytotoxic T lymphocytes and mast cell lipid mediators contributes to pathogenesis of eosinophilic asthma
by: Xue, L, et al.
Published: (2017)

First 5-days follow-up and correlation study between urinary cysteinyl leukotrienes and edema values in primary spontaneous supratentorial intracerebral hemorrhage
by: Dolnenec-Baneva Natalija, et al.
Published: (2014-07-01)

Prostaglandin E2/Leukotriene B4 balance induced by Lutzomyia longipalpis saliva favors Leishmania infantum infection
by: Théo Araújo-Santos, et al.
Published: (2014-12-01)

Bronchoprotective role for endogenous prostaglandin E2.
by: Pavord, I, et al.
Published: (1995)

Regulatory ILC2—Role of IL-10 Producing ILC2 in Asthma
by: Nahal Emami Fard, et al.
Published: (2023-10-01)

The tumor promoter cysteinyl leukotriene receptor 1 regulates PD-L1 expression in colon cancer cells via the Wnt/β-catenin signaling axis
by: Shakti Ranjan Satapathy, et al.
Published: (2023-06-01)

A Double-Blind Non-inferiority Clinical Study of Montelukast, a Cysteinyl Leukotriene Receptor 1 Antagonist, Compared with Pranlukast in Patients with Seasonal Allergic Rhinitis
by: Kimihiro Okubo, et al.
Published: (2008-01-01)

IL-6 effector function of group 2 innate lymphoid cells (ILC2) is NOD2 dependent
by: Hardman, CS, et al.
Published: (2021)

Prostaglandin E2 Enhances Gap Junctional Intercellular Communication in Clonal Epithelial Cells
by: Alejandro Ogazon del Toro, et al.
Published: (2021-05-01)

Leukotriene antagonists and symptom control in chronic persistent asthma.
by: Green, R, et al.
Published: (2001)

Inhibition of asthma-related immunological responses in mast cells and Th2 cell lines by cultured epithelial cell lines
by: Powell, T, et al.
Published: (2016)

A review of the therapeutic potential of the cysteinyl leukotriene antagonist Montelukast in the treatment of bronchiolitis obliterans syndrome following lung and hematopoietic-stem cell transplantation and its possible mechanisms
by: Nastaran Kordjazy, et al.
Published: (2024-03-01)

ILC2s in skin disorders
by: Yasutomo Imai
Published: (2023-04-01)

Editorial: Heterogeneity of ILC2s
by: Hiroki Kabata, et al.
Published: (2023-06-01)

Fevipiprant, a selective prostaglandin D2 receptor 2 antagonist, inhibits human group 2 innate lymphoid cell aggregation and function
by: Hardman, C, et al.
Published: (2019)