Monitoring poly(ADP-ribosyl)glycohydrolase activity with a continuous fluorescent substrate

The post-translational modification (PTM) and signaling molecule poly(ADP-ribose) (PAR) has an impact on diverse biological processes. This PTM is regulated by a series of ADP-ribosyl glycohydrolases (PARG enzymes) that cleave polymers and/or liberate monomers from their protein targets. Existing me...

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Príomhchruthaitheoirí: Drown, B, Shirai, T, Rack, J, Ahel, I, Hergenrother, P
Formáid: Journal article
Teanga:English
Foilsithe / Cruthaithe: Cell Press 2018