Pharmacogenetic analyses of 2183 patients with advanced colorectal cancer; potential role for common dihydropyrimidine dehydrogenase variants in toxicity to chemotherapy

<p><strong>Background</strong> Inherited genetic variants may influence response to, and side-effects from, chemotherapy. We sought to generate a comprehensive inherited pharmacogenetic profile for oxaliplatin and 5FU/capecitabine therapy in advanced colorectal cancer (aCRC).</p...

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Main Authors: Madi, A, Fisher, D, Maughan, T, Colley, J, Meade, A, Maynard, J, Humphreys, V, Wasan, H, Adams, R, Idziaszczyk, S, Harris, R, Kaplan, R, Cheadle, J
格式: Journal article
語言:English
出版: Elsevier 2018