Kinetic and crystallographic studies on deacetoxycephalosporin C synthase (DAOCS).

Kinetic and crystallographic studies on deacetoxycephalosporin C synthase (DAOCS).

Deacetoxycephalosporin C synthase (DAOCS) is an iron(II) and 2-oxoglutarate-dependent oxygenase that catalyzes the conversion of penicillin N to deacetoxycephalosporin C, the committed step in the biosynthesis of cephalosporin antibiotics. The crystal structure of DAOCS revealed that the C terminus...

पूर्ण विवरण

ग्रंथसूची विवरण
मुख्य लेखकों:	Lee, H, Lloyd, MD, Harlos, K, Clifton, I, Baldwin, J, Schofield, C
स्वरूप:	Journal article
भाषा:	English
प्रकाशित:	2001

समान संसाधन

Adipoyl-6-aminopenicillanic acid is a substrate for deacetoxycephalosporin C synthase (DAOCS)
द्वारा: Shibata, N, और अन्य
प्रकाशित: (1996)

Alteration of the co-substrate selectivity of deacetoxycephalosporin C synthase. The role of arginine 258.
द्वारा: Lee, H, और अन्य
प्रकाशित: (2001)

The effect of cysteine mutations on recombinant deacetoxycephalosporin C synthase from S. clavuligerus.
द्वारा: Lee, H, और अन्य
प्रकाशित: (2000)

Studies on the active site of deacetoxycephalosporin C synthase.
द्वारा: Lloyd, MD, और अन्य
प्रकाशित: (1999)

Controlling the substrate selectivity of deacetoxycephalosporin/deacetylcephalosporin C synthase.
द्वारा: Lloyd, MD, और अन्य
प्रकाशित: (2004)

The kinetic properties of various R258 mutants of deacetoxycephalosporin C synthase.
द्वारा: Lee, H, और अन्य
प्रकाशित: (2003)

Probing the penicillin sidechain selectivity of recombinant deacetoxycephalosporin C synthase.
द्वारा: Dubus, A, और अन्य
प्रकाशित: (2001)

Active site mutations of recombinant deacetoxycephalosporin C synthase.
द्वारा: Lee, H, और अन्य
प्रकाशित: (2002)

The role of arginine residues in substrate binding and catalysis by deacetoxycephalosporin C synthase.
द्वारा: Lipscomb, S, और अन्य
प्रकाशित: (2002)

Oxidation of deacetylcephalosporin C by deacetoxycephalosporin C/deacetylcephalosporin C synthase.
द्वारा: Baldwin, J, और अन्य
प्रकाशित: (1992)

Substrate specificity of cloned deacetoxycephalosporin C/deacetylcephalosporin C synthetase.
द्वारा: Baldwin, J, और अन्य
प्रकाशित: (1988)

Studies on deacetoxycephalosporin C synthase support a consensus mechanism for 2-oxoglutarate dependent oxygenases.
द्वारा: Tarhonskaya, H, और अन्य
प्रकाशित: (2014)

Deacetoxycephalosporin C synthase (expandase): Research progress and application potential
द्वारा: Xiaofan Niu, और अन्य
प्रकाशित: (2021-12-01)

STEPWISE HYDROGEN REMOVAL IN THE ENZYMATIC RING EXPANSION OF PENICILLIN-N TO DEACETOXYCEPHALOSPORIN-C
द्वारा: Baldwin, J, और अन्य
प्रकाशित: (1987)

Purification and initial characterization of an enzyme with deacetoxycephalosporin C synthetase and hydroxylase activities.
द्वारा: Baldwin, J, और अन्य
प्रकाशित: (1987)

Crystallographic studies on the binding of selectively deuterated LLD- and LLL-substrate epimers by isopenicillin N synthase.
द्वारा: Ge, W, और अन्य
प्रकाशित: (2010)

Kinetic and crystallographic analysis of complexes formed between elastase and peptides from beta-casein.
द्वारा: Wright, P, और अन्य
प्रकाशित: (2001)

The mechanism of the enzymatic ring expansion of penicillin N to deacetoxycephalosporin C
द्वारा: Crouch, N, और अन्य
प्रकाशित: (1988)

Crystallographic snapshots of sulfur insertion by lipoyl synthase
द्वारा: Lanz, Nicholas D., और अन्य
प्रकाशित: (2018)

Crystal structure of isopenicillin N synthase is the first from a new structural family of enzymes.
द्वारा: Roach, P, और अन्य
प्रकाशित: (1995)

Structural origins of the selectivity of the trifunctional oxygenase clavaminic acid synthase.
द्वारा: Zhang, Z, और अन्य
प्रकाशित: (2000)

SUBSTRATE-ANALOG STUDIES ON CLAVAMINIC ACID SYNTHASE
द्वारा: Baldwin, J, और अन्य
प्रकाशित: (1993)

Crystal structure of a clavaminate synthase-Fe(II)-2-oxoglutarate-substrate-NO complex: evidence for metal centered rearrangements.
द्वारा: Zhang, Z, और अन्य
प्रकाशित: (2002)

Crystal structure of carbapenem synthase (CarC).
द्वारा: Clifton, I, और अन्य
प्रकाशित: (2003)

Structure of a cephalosporin synthase.
द्वारा: Valegård, K, और अन्य
प्रकाशित: (1998)

Structure of proline 3-hydroxylase. Evolution of the family of 2-oxoglutarate dependent oxygenases.
द्वारा: Clifton, I, और अन्य
प्रकाशित: (2001)

'pH-jump' crystallographic analyses of gamma-lactam-porcine pancreatic elastase complexes.
द्वारा: Wright, P, और अन्य
प्रकाशित: (2000)

Crystallization and preliminary X-ray diffraction studies on recombinant isopenicillin N synthase from Aspergillus nidulans.
द्वारा: Roach, P, और अन्य
प्रकाशित: (1995)

Crystallographic structure of the turbine C-ring from spinach chloroplast F-ATP synthase
द्वारा: Seelert, Holger, और अन्य
प्रकाशित: (2014)

Qualité des produits et ancrage au terroir : le cas des filières fromagères d'AOC du Massif Central
द्वारा: J.B. COULON, और अन्य
प्रकाशित: (1998-04-01)

Structure of isopenicillin N synthase complexed with substrate and the mechanism of penicillin formation.
द्वारा: Roach, P, और अन्य
प्रकाशित: (1997)

Solution and crystallographic structures of the central region of the phosphoprotein from human metapneumovirus
द्वारा: Leyrat, C, और अन्य
प्रकाशित: (2013)

Chemo-enzymatic synthesis of bicyclic gamma-lactams using clavaminic acid synthase
द्वारा: Baldwin, J, और अन्य
प्रकाशित: (1997)

EXAFS STUDIES OF ISOPENICILLIN-N SYNTHASE
द्वारा: Randall, C, और अन्य
प्रकाशित: (1992)

ISOPENICILLIN-N SYNTHASE - A NEW MODE OF REACTIVITY
द्वारा: Baldwin, J, और अन्य
प्रकाशित: (1991)

ISOPENICILLIN-N SYNTHASE - A NEW MODE OF REACTIVITY
द्वारा: Baldwin, J, और अन्य
प्रकाशित: (1992)

Product-substrate engineering by bacteria: Studies on clavaminate synthase, a trifunctional dioxygenase
द्वारा: Lloyd, MD, और अन्य
प्रकाशित: (1999)

Structural studies on the reaction of isopenicillin N synthase with the substrate analogue delta-(l-alpha-aminoadipoyl)-l-cysteinyl-d-alpha-aminobutyrate.
द्वारा: Long, A, और अन्य
प्रकाशित: (2003)

Structural and mechanistic studies on anthocyanidin synthase catalysed oxidation of flavanone substrates: the effect of C-2 stereochemistry on product selectivity and mechanism.
द्वारा: Welford, R, और अन्य
प्रकाशित: (2005)

ENZYMATIC-SYNTHESIS OF BICYCLIC GAMMA-LACTAMS USING CLAVAMINIC ACID SYNTHASE
द्वारा: Baldwin, J, और अन्य
प्रकाशित: (1992)