The dual action of human antibodies specific to Plasmodium falciparum PfRH5 and PfCyRPA: Blocking invasion and inactivating extracellular merozoites

The dual action of human antibodies specific to Plasmodium falciparum PfRH5 and PfCyRPA: Blocking invasion and inactivating extracellular merozoites

The Plasmodium falciparum reticulocyte-binding protein homolog 5 (PfRH5) is the current leading blood-stage malaria vaccine candidate. PfRH5 functions as part of the pentameric PCRCR complex containing PTRAMP, CSS, PfCyRPA and PfRIPR, all of which are essential for infection of human red blood cells...

Disgrifiad llawn

Manylion Llyfryddiaeth
Prif Awduron:	Weiss, GE, Ragotte, RJ, Quinkert, D, Lias, AM, Dans, MG, Boulet, C, Looker, O, Ventura, OD, Williams, BG, Crabb, BS, Draper, SJ, Gilson, PR
Fformat:	Journal article
Iaith:	English
Cyhoeddwyd:	Public Library of Science 2023

Eitemau Tebyg

The dual action of human antibodies specific to Plasmodium falciparum PfRH5 and PfCyRPA: Blocking invasion and inactivating extracellular merozoites.
gan: Greta E Weiss, et al.
Cyhoeddwyd: (2023-09-01)

The molecular basis of Plasmodium falciparum merozoite invasion inhibition via anti-PfCyRPA antibodies
gan: Ragotte, R
Cyhoeddwyd: (2020)

The essential malaria protein PfCyRPA targets glycans to invade erythrocytes
gan: Christopher J. Day, et al.
Cyhoeddwyd: (2024-04-01)

Targeting PfRh5 on Merozoites to Prevent Basigin Binding
gan: Papadopoulos Konstantinos
Cyhoeddwyd: (2012-10-01)

Neutralization of Plasmodium falciparum merozoites by antibodies against PfRH5.
gan: Douglas, A, et al.
Cyhoeddwyd: (2014)

Leveraging Immunofocusing and Virus-like Particle Display to Enhance Antibody Responses to the Malaria Blood-Stage Invasion Complex Antigen PfCyRPA
gan: Kasper H. Björnsson, et al.
Cyhoeddwyd: (2024-07-01)

Scalable Process for High-Yield Production of PfCyRPA Using Insect Cells for Inclusion in a Malaria Virosome-Based Vaccine Candidate
gan: Bárbara Fernandes, et al.
Cyhoeddwyd: (2022-05-01)

Antibodies targeting the PfRH1 binding domain inhibit invasion of plasmodium falciparum merozoites
gan: Iyer, Jayasree K., et al.
Cyhoeddwyd: (2011)

Antibodies targeting the PfRH1 binding domain inhibit invasion of Plasmodium falciparum merozoites.
gan: Xiaohong Gao, et al.
Cyhoeddwyd: (2008-07-01)

The malaria blood stage antigen PfCyRPA formulated with the TLR-4 agonist adjuvant GLA-SE elicits parasite growth inhibitory antibodies in experimental animals
gan: Marco Tamborrini, et al.
Cyhoeddwyd: (2023-07-01)

Plasmodium falciparum merozoite invasion is inhibited by antibodies that target the PfRh2a and b binding domains.
gan: Tony Triglia, et al.
Cyhoeddwyd: (2011-06-01)

Enhancing blockade of Plasmodium falciparum erythrocyte invasion: assessing combinations of antibodies against PfRH5 and other merozoite antigens.
gan: Williams, A, et al.
Cyhoeddwyd: (2012)

Enhancing blockade of Plasmodium falciparum erythrocyte invasion: assessing combinations of antibodies against PfRH5 and other merozoite antigens.
gan: Andrew R Williams, et al.
Cyhoeddwyd: (2012-01-01)

Rational structure-guided design of a blood stage malaria vaccine immunogen presenting a single epitope from PfRH5
gan: Harrison, TE, et al.
Cyhoeddwyd: (2024)

A full-length recombinant Plasmodium falciparum PfRH5 protein induces inhibitory antibodies that are effective across common PfRH5 genetic variants
gan: Bustamante, L, et al.
Cyhoeddwyd: (2013)

The RH5-CyRPA-Ripr complex as a malaria vaccine target
gan: Ragotte, RJ, et al.
Cyhoeddwyd: (2020)

Rational structure-guided design of a blood stage malaria vaccine immunogen presenting a single epitope from PfRH5
gan: Thomas E Harrison, et al.
Cyhoeddwyd: (2024-09-01)

Assessment of precision in growth inhibition assay (GIA) using human anti-PfRH5 antibodies
gan: Miura, K, et al.
Cyhoeddwyd: (2023)

Kinetics of antibody responses to PfRH5-complex antigens in Ghanaian children with Plasmodium falciparum malaria
gan: Partey, F, et al.
Cyhoeddwyd: (2018)

The erythrocyte binding antigens and PfRh proteins are targets of Plasmodium falciparum invasioninhibitory antibodies.
gan: Persson, K, et al.
Cyhoeddwyd: (2008)

Assessment of precision in growth inhibition assay (GIA) using human anti-PfRH5 antibodies
gan: Kazutoyo Miura, et al.
Cyhoeddwyd: (2023-05-01)

Kinetics of antibody responses to PfRH5-complex antigens in Ghanaian children with Plasmodium falciparum malaria.
gan: Frederica D Partey, et al.
Cyhoeddwyd: (2018-01-01)

The role of PfRh invasion ligands as targets of antibodies that protect against P-falciparum malaria.
gan: Reiling, L, et al.
Cyhoeddwyd: (2008)

Crystal structure of PfRh5, an essential P. falciparum ligand for invasion of human erythrocytes
gan: Lin Chen, et al.
Cyhoeddwyd: (2014-10-01)

Correction: Kinetics of antibody responses to PfRH5-complex antigens in Ghanaian children with Plasmodium falciparum malaria.
gan: Frederica D Partey, et al.
Cyhoeddwyd: (2018-01-01)

The blood-stage malaria antigen PfRH5 is susceptible to vaccine-inducible cross-strain neutralizing antibody.
gan: Douglas, A, et al.
Cyhoeddwyd: (2011)

Functional characterization of plasmodium falciparum reticulocyte binding like protein homologue 1 (PfRH1)
gan: Yap, Sally Shu Lin
Cyhoeddwyd: (2015)

Insights into the design of an improved PfRH5 malaria immunogen using vaccine-induced monoclonal antibodies
gan: Alanine, DGW
Cyhoeddwyd: (2017)

The EBA and PfRh invasion ligand families of P-falciparum as targets of invasion-inhibitory and protective antibodies.
gan: Beeson, J, et al.
Cyhoeddwyd: (2008)

Plasmepsin X activates the PCRCR complex of Plasmodium falciparum by processing PfRh5 for erythrocyte invasion
gan: Tony Triglia, et al.
Cyhoeddwyd: (2023-04-01)

Establishment of an Antiplasmodial Vaccine Based on PfRH5-Encoding RNA Replicons Stabilized by Cationic Liposomes
gan: Wesley L. Fotoran, et al.
Cyhoeddwyd: (2023-04-01)

Assessing the functional impact of PfRh5 genetic diversity on ex vivo erythrocyte invasion inhibition
gan: Adam J. Moore, et al.
Cyhoeddwyd: (2021-01-01)

Structure-guided insights into potential function of novel genetic variants in the malaria vaccine candidate PfRh5
gan: Khadidiatou Mangou, et al.
Cyhoeddwyd: (2022-11-01)

Development of an improved blood-stage malaria vaccine targeting the essential RH5-CyRPA-RIPR invasion complex
gan: Williams, BG, et al.
Cyhoeddwyd: (2024)

An EGF-like protein forms a complex with PfRh5 and is required for invasion of human erythrocytes by Plasmodium falciparum.
gan: Lin Chen, et al.
Cyhoeddwyd: (2011-09-01)

Correction: PfRH5: A Novel Reticulocyte-Binding Family Homolog of that Binds to the Erythrocyte, and an Investigation of Its Receptor.
gan: Marilis Rodriguez, et al.
Cyhoeddwyd: (2008-01-01)

Vaccine-induced human monoclonal antibodies to PfRH5 show broadly neutralizing activity against P. falciparum clinical isolates
gan: Thiam, LG, et al.
Cyhoeddwyd: (2024)

A PfRH5-based vaccine is efficacious against heterologous strain blood-stage Plasmodium falciparum infection in aotus monkeys.
gan: Douglas, A, et al.
Cyhoeddwyd: (2015)

Vaccine-induced human monoclonal antibodies to PfRH5 show broadly neutralizing activity against P. falciparum clinical isolates
gan: Laty G. Thiam, et al.
Cyhoeddwyd: (2024-10-01)

A DNA Vaccine Encoding <i>Plasmodium falciparum</i> PfRH5 in Cationic Liposomes for Dermal Tattooing Immunization
gan: Wesley Luzetti Fotoran, et al.
Cyhoeddwyd: (2020-10-01)