The dual action of human antibodies specific to Plasmodium falciparum PfRH5 and PfCyRPA: Blocking invasion and inactivating extracellular merozoites

The dual action of human antibodies specific to Plasmodium falciparum PfRH5 and PfCyRPA: Blocking invasion and inactivating extracellular merozoites

The Plasmodium falciparum reticulocyte-binding protein homolog 5 (PfRH5) is the current leading blood-stage malaria vaccine candidate. PfRH5 functions as part of the pentameric PCRCR complex containing PTRAMP, CSS, PfCyRPA and PfRIPR, all of which are essential for infection of human red blood cells...

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς:	Weiss, GE, Ragotte, RJ, Quinkert, D, Lias, AM, Dans, MG, Boulet, C, Looker, O, Ventura, OD, Williams, BG, Crabb, BS, Draper, SJ, Gilson, PR
Μορφή:	Journal article
Γλώσσα:	English
Έκδοση:	Public Library of Science 2023

Παρόμοια τεκμήρια

The dual action of human antibodies specific to Plasmodium falciparum PfRH5 and PfCyRPA: Blocking invasion and inactivating extracellular merozoites.
ανά: Greta E Weiss, κ.ά.
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The molecular basis of Plasmodium falciparum merozoite invasion inhibition via anti-PfCyRPA antibodies
ανά: Ragotte, R
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The essential malaria protein PfCyRPA targets glycans to invade erythrocytes
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Targeting PfRh5 on Merozoites to Prevent Basigin Binding
ανά: Papadopoulos Konstantinos
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Neutralization of Plasmodium falciparum merozoites by antibodies against PfRH5.
ανά: Douglas, A, κ.ά.
Έκδοση: (2014)

Leveraging Immunofocusing and Virus-like Particle Display to Enhance Antibody Responses to the Malaria Blood-Stage Invasion Complex Antigen PfCyRPA
ανά: Kasper H. Björnsson, κ.ά.
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Scalable Process for High-Yield Production of PfCyRPA Using Insect Cells for Inclusion in a Malaria Virosome-Based Vaccine Candidate
ανά: Bárbara Fernandes, κ.ά.
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Antibodies targeting the PfRH1 binding domain inhibit invasion of plasmodium falciparum merozoites
ανά: Iyer, Jayasree K., κ.ά.
Έκδοση: (2011)

Antibodies targeting the PfRH1 binding domain inhibit invasion of Plasmodium falciparum merozoites.
ανά: Xiaohong Gao, κ.ά.
Έκδοση: (2008-07-01)

The malaria blood stage antigen PfCyRPA formulated with the TLR-4 agonist adjuvant GLA-SE elicits parasite growth inhibitory antibodies in experimental animals
ανά: Marco Tamborrini, κ.ά.
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Plasmodium falciparum merozoite invasion is inhibited by antibodies that target the PfRh2a and b binding domains.
ανά: Tony Triglia, κ.ά.
Έκδοση: (2011-06-01)

Enhancing blockade of Plasmodium falciparum erythrocyte invasion: assessing combinations of antibodies against PfRH5 and other merozoite antigens.
ανά: Williams, A, κ.ά.
Έκδοση: (2012)

Enhancing blockade of Plasmodium falciparum erythrocyte invasion: assessing combinations of antibodies against PfRH5 and other merozoite antigens.
ανά: Andrew R Williams, κ.ά.
Έκδοση: (2012-01-01)

Rational structure-guided design of a blood stage malaria vaccine immunogen presenting a single epitope from PfRH5
ανά: Harrison, TE, κ.ά.
Έκδοση: (2024)

A full-length recombinant Plasmodium falciparum PfRH5 protein induces inhibitory antibodies that are effective across common PfRH5 genetic variants
ανά: Bustamante, L, κ.ά.
Έκδοση: (2013)

The RH5-CyRPA-Ripr complex as a malaria vaccine target
ανά: Ragotte, RJ, κ.ά.
Έκδοση: (2020)

Rational structure-guided design of a blood stage malaria vaccine immunogen presenting a single epitope from PfRH5
ανά: Thomas E Harrison, κ.ά.
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Assessment of precision in growth inhibition assay (GIA) using human anti-PfRH5 antibodies
ανά: Miura, K, κ.ά.
Έκδοση: (2023)

Kinetics of antibody responses to PfRH5-complex antigens in Ghanaian children with Plasmodium falciparum malaria
ανά: Partey, F, κ.ά.
Έκδοση: (2018)

The erythrocyte binding antigens and PfRh proteins are targets of Plasmodium falciparum invasioninhibitory antibodies.
ανά: Persson, K, κ.ά.
Έκδοση: (2008)

Assessment of precision in growth inhibition assay (GIA) using human anti-PfRH5 antibodies
ανά: Kazutoyo Miura, κ.ά.
Έκδοση: (2023-05-01)

Kinetics of antibody responses to PfRH5-complex antigens in Ghanaian children with Plasmodium falciparum malaria.
ανά: Frederica D Partey, κ.ά.
Έκδοση: (2018-01-01)

The role of PfRh invasion ligands as targets of antibodies that protect against P-falciparum malaria.
ανά: Reiling, L, κ.ά.
Έκδοση: (2008)

Crystal structure of PfRh5, an essential P. falciparum ligand for invasion of human erythrocytes
ανά: Lin Chen, κ.ά.
Έκδοση: (2014-10-01)

Correction: Kinetics of antibody responses to PfRH5-complex antigens in Ghanaian children with Plasmodium falciparum malaria.
ανά: Frederica D Partey, κ.ά.
Έκδοση: (2018-01-01)

The blood-stage malaria antigen PfRH5 is susceptible to vaccine-inducible cross-strain neutralizing antibody.
ανά: Douglas, A, κ.ά.
Έκδοση: (2011)

Functional characterization of plasmodium falciparum reticulocyte binding like protein homologue 1 (PfRH1)
ανά: Yap, Sally Shu Lin
Έκδοση: (2015)

Insights into the design of an improved PfRH5 malaria immunogen using vaccine-induced monoclonal antibodies
ανά: Alanine, DGW
Έκδοση: (2017)

The EBA and PfRh invasion ligand families of P-falciparum as targets of invasion-inhibitory and protective antibodies.
ανά: Beeson, J, κ.ά.
Έκδοση: (2008)

Plasmepsin X activates the PCRCR complex of Plasmodium falciparum by processing PfRh5 for erythrocyte invasion
ανά: Tony Triglia, κ.ά.
Έκδοση: (2023-04-01)

Establishment of an Antiplasmodial Vaccine Based on PfRH5-Encoding RNA Replicons Stabilized by Cationic Liposomes
ανά: Wesley L. Fotoran, κ.ά.
Έκδοση: (2023-04-01)

Assessing the functional impact of PfRh5 genetic diversity on ex vivo erythrocyte invasion inhibition
ανά: Adam J. Moore, κ.ά.
Έκδοση: (2021-01-01)

Structure-guided insights into potential function of novel genetic variants in the malaria vaccine candidate PfRh5
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Έκδοση: (2022-11-01)

Development of an improved blood-stage malaria vaccine targeting the essential RH5-CyRPA-RIPR invasion complex
ανά: Williams, BG, κ.ά.
Έκδοση: (2024)

An EGF-like protein forms a complex with PfRh5 and is required for invasion of human erythrocytes by Plasmodium falciparum.
ανά: Lin Chen, κ.ά.
Έκδοση: (2011-09-01)

Correction: PfRH5: A Novel Reticulocyte-Binding Family Homolog of that Binds to the Erythrocyte, and an Investigation of Its Receptor.
ανά: Marilis Rodriguez, κ.ά.
Έκδοση: (2008-01-01)

Vaccine-induced human monoclonal antibodies to PfRH5 show broadly neutralizing activity against P. falciparum clinical isolates
ανά: Thiam, LG, κ.ά.
Έκδοση: (2024)

A PfRH5-based vaccine is efficacious against heterologous strain blood-stage Plasmodium falciparum infection in aotus monkeys.
ανά: Douglas, A, κ.ά.
Έκδοση: (2015)

Vaccine-induced human monoclonal antibodies to PfRH5 show broadly neutralizing activity against P. falciparum clinical isolates
ανά: Laty G. Thiam, κ.ά.
Έκδοση: (2024-10-01)

A DNA Vaccine Encoding <i>Plasmodium falciparum</i> PfRH5 in Cationic Liposomes for Dermal Tattooing Immunization
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