Development of an enolate alkynylation approach towards the synthesis of the taiwanschirin natural products
Through the use of model studies, an approach was conceived towards the synthesis of the taiwanschirin family of natural products. These are structurally complex compounds which represent highly challenging and biologically active targets for total synthesis. This work describes a successful synthes...
| Main Authors: | , , , |
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| Format: | Journal article |
| Language: | English |
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Royal Society of Chemistry
2021
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| _version_ | 1826284785754963968 |
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| author | Haughey, M Poole, D Christensen, K Donohoe, T |
| author_facet | Haughey, M Poole, D Christensen, K Donohoe, T |
| author_sort | Haughey, M |
| collection | OXFORD |
| description | Through the use of model studies, an approach was conceived towards the synthesis of the taiwanschirin family of natural products. These are structurally complex compounds which represent highly challenging and biologically active targets for total synthesis. This work describes a successful synthesis of the complex taiwanschirin fused [8,6,5] core through a novel alkynylation reaction coupled with an intramolecular Heck reaction used to construct the 8–membered ring. |
| first_indexed | 2024-03-07T01:19:04Z |
| format | Journal article |
| id | oxford-uuid:8fb8b83b-c574-48dc-8a79-f9fa3d279819 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T01:19:04Z |
| publishDate | 2021 |
| publisher | Royal Society of Chemistry |
| record_format | dspace |
| spelling | oxford-uuid:8fb8b83b-c574-48dc-8a79-f9fa3d2798192022-03-26T23:06:24ZDevelopment of an enolate alkynylation approach towards the synthesis of the taiwanschirin natural productsJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:8fb8b83b-c574-48dc-8a79-f9fa3d279819EnglishSymplectic ElementsRoyal Society of Chemistry2021Haughey, MPoole, DChristensen, KDonohoe, TThrough the use of model studies, an approach was conceived towards the synthesis of the taiwanschirin family of natural products. These are structurally complex compounds which represent highly challenging and biologically active targets for total synthesis. This work describes a successful synthesis of the complex taiwanschirin fused [8,6,5] core through a novel alkynylation reaction coupled with an intramolecular Heck reaction used to construct the 8–membered ring. |
| spellingShingle | Haughey, M Poole, D Christensen, K Donohoe, T Development of an enolate alkynylation approach towards the synthesis of the taiwanschirin natural products |
| title | Development of an enolate alkynylation approach towards the synthesis of the taiwanschirin natural products |
| title_full | Development of an enolate alkynylation approach towards the synthesis of the taiwanschirin natural products |
| title_fullStr | Development of an enolate alkynylation approach towards the synthesis of the taiwanschirin natural products |
| title_full_unstemmed | Development of an enolate alkynylation approach towards the synthesis of the taiwanschirin natural products |
| title_short | Development of an enolate alkynylation approach towards the synthesis of the taiwanschirin natural products |
| title_sort | development of an enolate alkynylation approach towards the synthesis of the taiwanschirin natural products |
| work_keys_str_mv | AT haugheym developmentofanenolatealkynylationapproachtowardsthesynthesisofthetaiwanschirinnaturalproducts AT pooled developmentofanenolatealkynylationapproachtowardsthesynthesisofthetaiwanschirinnaturalproducts AT christensenk developmentofanenolatealkynylationapproachtowardsthesynthesisofthetaiwanschirinnaturalproducts AT donohoet developmentofanenolatealkynylationapproachtowardsthesynthesisofthetaiwanschirinnaturalproducts |