Expanding role of AMPK in endocrinology.
Adenosine 5' monophosphate-activated protein kinase (AMPK) is a regulator of cellular and systemic energy homeostasis. It mediates some of the effects of peripheral hormones such as leptin, ghrelin and adiponectin, and it is involved in the insulin-sensitizing role of the antidiabetic drug metf...
| Main Authors: | , , , , |
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| Format: | Journal article |
| Language: | English |
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2006
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| _version_ | 1797081797375295488 |
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| author | Kola, B Boscaro, M Rutter, G Grossman, AB Korbonits, M |
| author_facet | Kola, B Boscaro, M Rutter, G Grossman, AB Korbonits, M |
| author_sort | Kola, B |
| collection | OXFORD |
| description | Adenosine 5' monophosphate-activated protein kinase (AMPK) is a regulator of cellular and systemic energy homeostasis. It mediates some of the effects of peripheral hormones such as leptin, ghrelin and adiponectin, and it is involved in the insulin-sensitizing role of the antidiabetic drug metformin. There is increasing evidence that AMPK has a central role in mediating the appetite-modulating and metabolic effects of many other hormones and substances, including the cannabinoids. Recent studies have illustrated the interaction between hormones and AMPK, and highlighted AMPK as a potential target for the development of tissue-specific AMPK modulators in the treatment of obesity and the metabolic syndrome. |
| first_indexed | 2024-03-07T01:19:05Z |
| format | Journal article |
| id | oxford-uuid:8fb9ffdd-6989-4b00-8d3b-3631369a9ec2 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T01:19:05Z |
| publishDate | 2006 |
| record_format | dspace |
| spelling | oxford-uuid:8fb9ffdd-6989-4b00-8d3b-3631369a9ec22022-03-26T23:06:23ZExpanding role of AMPK in endocrinology.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:8fb9ffdd-6989-4b00-8d3b-3631369a9ec2EnglishSymplectic Elements at Oxford2006Kola, BBoscaro, MRutter, GGrossman, ABKorbonits, MAdenosine 5' monophosphate-activated protein kinase (AMPK) is a regulator of cellular and systemic energy homeostasis. It mediates some of the effects of peripheral hormones such as leptin, ghrelin and adiponectin, and it is involved in the insulin-sensitizing role of the antidiabetic drug metformin. There is increasing evidence that AMPK has a central role in mediating the appetite-modulating and metabolic effects of many other hormones and substances, including the cannabinoids. Recent studies have illustrated the interaction between hormones and AMPK, and highlighted AMPK as a potential target for the development of tissue-specific AMPK modulators in the treatment of obesity and the metabolic syndrome. |
| spellingShingle | Kola, B Boscaro, M Rutter, G Grossman, AB Korbonits, M Expanding role of AMPK in endocrinology. |
| title | Expanding role of AMPK in endocrinology. |
| title_full | Expanding role of AMPK in endocrinology. |
| title_fullStr | Expanding role of AMPK in endocrinology. |
| title_full_unstemmed | Expanding role of AMPK in endocrinology. |
| title_short | Expanding role of AMPK in endocrinology. |
| title_sort | expanding role of ampk in endocrinology |
| work_keys_str_mv | AT kolab expandingroleofampkinendocrinology AT boscarom expandingroleofampkinendocrinology AT rutterg expandingroleofampkinendocrinology AT grossmanab expandingroleofampkinendocrinology AT korbonitsm expandingroleofampkinendocrinology |