A pathway-specific function for different AMPA receptor subunits in amygdala long-term potentiation and fear conditioning.
The AMPA receptor subunit glutamate receptor 1 (GluR1 or GluR-A) contributes to amygdala-dependent emotional learning. It remains unclear, however, to what extent different amygdala pathways depend on GluR1, or other AMPA receptor subunits, for proper synaptic transmission and plasticity, and whethe...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
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2007
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| _version_ | 1826284845640187904 |
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| author | Humeau, Y Reisel, D Johnson, A Borchardt, T Jensen, V Gebhardt, C Bosch, V Gass, P Bannerman, D Good, M Hvalby, Ø Sprengel, R Lüthi, A |
| author_facet | Humeau, Y Reisel, D Johnson, A Borchardt, T Jensen, V Gebhardt, C Bosch, V Gass, P Bannerman, D Good, M Hvalby, Ø Sprengel, R Lüthi, A |
| author_sort | Humeau, Y |
| collection | OXFORD |
| description | The AMPA receptor subunit glutamate receptor 1 (GluR1 or GluR-A) contributes to amygdala-dependent emotional learning. It remains unclear, however, to what extent different amygdala pathways depend on GluR1, or other AMPA receptor subunits, for proper synaptic transmission and plasticity, and whether GluR1-dependent long-term potentiation (LTP) is necessary for auditory and contextual fear conditioning. Here, we dissected the role of GluR1 and GluR3 (GluR-C) subunits in AMPA receptor-dependent amygdala LTP and fear conditioning using knock-out mice (GluR1-/- and GluR3-/-). We found that, whereas LTP at thalamic inputs to lateral amygdala (LA) projection neurons and at glutamatergic synapses in the basal amygdala was completely absent in GluR1-/- mice, both GluR1 and GluR3 contributed to LTP in the cortico-LA pathway. Because both auditory and contextual fear conditioning were selectively impaired in GluR1-/- but not GluR3-/- mice, we conclude that GluR1-dependent synaptic plasticity is the dominant form of LTP underlying the acquisition of auditory and contextual fear conditioning, and that plasticity in distinct amygdala pathways differentially contributes to aversive conditioning. |
| first_indexed | 2024-03-07T01:19:58Z |
| format | Journal article |
| id | oxford-uuid:8ffc1dec-2c6e-48ea-847e-9d3497466f80 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T01:19:58Z |
| publishDate | 2007 |
| record_format | dspace |
| spelling | oxford-uuid:8ffc1dec-2c6e-48ea-847e-9d3497466f802022-03-26T23:08:22ZA pathway-specific function for different AMPA receptor subunits in amygdala long-term potentiation and fear conditioning.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:8ffc1dec-2c6e-48ea-847e-9d3497466f80EnglishSymplectic Elements at Oxford2007Humeau, YReisel, DJohnson, ABorchardt, TJensen, VGebhardt, CBosch, VGass, PBannerman, DGood, MHvalby, ØSprengel, RLüthi, AThe AMPA receptor subunit glutamate receptor 1 (GluR1 or GluR-A) contributes to amygdala-dependent emotional learning. It remains unclear, however, to what extent different amygdala pathways depend on GluR1, or other AMPA receptor subunits, for proper synaptic transmission and plasticity, and whether GluR1-dependent long-term potentiation (LTP) is necessary for auditory and contextual fear conditioning. Here, we dissected the role of GluR1 and GluR3 (GluR-C) subunits in AMPA receptor-dependent amygdala LTP and fear conditioning using knock-out mice (GluR1-/- and GluR3-/-). We found that, whereas LTP at thalamic inputs to lateral amygdala (LA) projection neurons and at glutamatergic synapses in the basal amygdala was completely absent in GluR1-/- mice, both GluR1 and GluR3 contributed to LTP in the cortico-LA pathway. Because both auditory and contextual fear conditioning were selectively impaired in GluR1-/- but not GluR3-/- mice, we conclude that GluR1-dependent synaptic plasticity is the dominant form of LTP underlying the acquisition of auditory and contextual fear conditioning, and that plasticity in distinct amygdala pathways differentially contributes to aversive conditioning. |
| spellingShingle | Humeau, Y Reisel, D Johnson, A Borchardt, T Jensen, V Gebhardt, C Bosch, V Gass, P Bannerman, D Good, M Hvalby, Ø Sprengel, R Lüthi, A A pathway-specific function for different AMPA receptor subunits in amygdala long-term potentiation and fear conditioning. |
| title | A pathway-specific function for different AMPA receptor subunits in amygdala long-term potentiation and fear conditioning. |
| title_full | A pathway-specific function for different AMPA receptor subunits in amygdala long-term potentiation and fear conditioning. |
| title_fullStr | A pathway-specific function for different AMPA receptor subunits in amygdala long-term potentiation and fear conditioning. |
| title_full_unstemmed | A pathway-specific function for different AMPA receptor subunits in amygdala long-term potentiation and fear conditioning. |
| title_short | A pathway-specific function for different AMPA receptor subunits in amygdala long-term potentiation and fear conditioning. |
| title_sort | pathway specific function for different ampa receptor subunits in amygdala long term potentiation and fear conditioning |
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