Regulatory T cells in transplantation: transferring mouse studies to the clinic.
Switching the balance from rejection of major histocompatibility-mismatched grafts toward long-term tolerance of donor grafts, with the need for minimal immunosuppressive drugs, is a major transplantation goal. Regulatory T cells (Treg) can induce and maintain antigen-specific immune tolerance and f...
| Main Authors: | , |
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| Format: | Journal article |
| Language: | English |
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2009
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| _version_ | 1797081857889665024 |
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| author | Long, E Wood, K |
| author_facet | Long, E Wood, K |
| author_sort | Long, E |
| collection | OXFORD |
| description | Switching the balance from rejection of major histocompatibility-mismatched grafts toward long-term tolerance of donor grafts, with the need for minimal immunosuppressive drugs, is a major transplantation goal. Regulatory T cells (Treg) can induce and maintain antigen-specific immune tolerance and facilitate allogeneic graft survival successfully in animals. This review will focus on the valuable insights experimental mouse models have given us into the effects of currently used immunosuppressive reagents on Treg, the Treg transcription factor forkhead box P3, and strategies to expand or induce alloantigen-reactive Treg in vivo and in vitro. These have facilitated the translation of strategies for promoting transplantation tolerance towards a new clinical era. |
| first_indexed | 2024-03-07T01:19:59Z |
| format | Journal article |
| id | oxford-uuid:8ffdbee7-dd59-4539-bad3-ecb4515ca648 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T01:19:59Z |
| publishDate | 2009 |
| record_format | dspace |
| spelling | oxford-uuid:8ffdbee7-dd59-4539-bad3-ecb4515ca6482022-03-26T23:08:25ZRegulatory T cells in transplantation: transferring mouse studies to the clinic.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:8ffdbee7-dd59-4539-bad3-ecb4515ca648EnglishSymplectic Elements at Oxford2009Long, EWood, KSwitching the balance from rejection of major histocompatibility-mismatched grafts toward long-term tolerance of donor grafts, with the need for minimal immunosuppressive drugs, is a major transplantation goal. Regulatory T cells (Treg) can induce and maintain antigen-specific immune tolerance and facilitate allogeneic graft survival successfully in animals. This review will focus on the valuable insights experimental mouse models have given us into the effects of currently used immunosuppressive reagents on Treg, the Treg transcription factor forkhead box P3, and strategies to expand or induce alloantigen-reactive Treg in vivo and in vitro. These have facilitated the translation of strategies for promoting transplantation tolerance towards a new clinical era. |
| spellingShingle | Long, E Wood, K Regulatory T cells in transplantation: transferring mouse studies to the clinic. |
| title | Regulatory T cells in transplantation: transferring mouse studies to the clinic. |
| title_full | Regulatory T cells in transplantation: transferring mouse studies to the clinic. |
| title_fullStr | Regulatory T cells in transplantation: transferring mouse studies to the clinic. |
| title_full_unstemmed | Regulatory T cells in transplantation: transferring mouse studies to the clinic. |
| title_short | Regulatory T cells in transplantation: transferring mouse studies to the clinic. |
| title_sort | regulatory t cells in transplantation transferring mouse studies to the clinic |
| work_keys_str_mv | AT longe regulatorytcellsintransplantationtransferringmousestudiestotheclinic AT woodk regulatorytcellsintransplantationtransferringmousestudiestotheclinic |