A specific nanobody prevents amyloidogenesis of D76N β2-microglobulin in vitro and modifies its tissue distribution in vivo.

A specific nanobody prevents amyloidogenesis of D76N β2-microglobulin in vitro and modifies its tissue distribution in vivo.

Systemic amyloidosis is caused by misfolding and aggregation of globular proteins in vivo for which effective treatments are urgently needed. Inhibition of protein self-aggregation represents an attractive therapeutic strategy. Studies on the amyloidogenic variant of β2-microglobulin, D76N, causing...

Full description

Bibliographic Details
Main Authors: Raimondi, S, Porcari, R, Mangione, P, Verona, G, Marcoux, J, Giorgetti, S, Taylor, G, Ellmerich, S, Ballico, M, Zanini, S, Pardon, E, Al-Shawi, R, Simons, J, Corazza, A, Fogolari, F, Leri, M, Stefani, M, Bucciantini, M, Gillmore, J, Hawkins, P, Valli, M, Stoppini, M, Robinson, C, Steyaert, J, Esposito, G, Bellotti, V
Format: Journal article
Language:English
Published: Nature Publishing Group 2017

Similar Items

Similar Items