| Summary: | <p><strong>Objective:</strong> To develop evidence-based clinical practice recommendations regarding transfusion practices in non-bleeding, critically ill adults.</p>
<p><strong>Design:</strong> A task force involving 13 international experts and three methodologists used the GRADE approach for guideline development.</p>
<p><strong>Methods:</strong> The task force identified four main topics: red blood cell transfusion thresholds, red blood cell transfusion avoidance strategies, platelet transfusion, and plasma transfusion. The panel developed structured guideline questions using population, intervention, comparison, and outcomes (PICO) format.</p>
<p><strong>Results:</strong> The task force generated 16 clinical practice recommendations (3 strong recommendations, 13 conditional recommendations), and identified five PICOs with insufficient evidence to make any recommendation.</p>
<p><strong>Conclusions:</strong> This clinical practice guideline provides evidence-based recommendations and identifies areas where further research is needed regarding transfusion practices and transfusion avoidance in non-bleeding, critically ill adults.</p>
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