CD4 mAbs prevent progression of alloactivated CD4+ T cells into the S phase of the cell cycle without interfering with early activation signals.

CD4 mAbs prevent progression of alloactivated CD4+ T cells into the S phase of the cell cycle without interfering with early activation signals.

Knowing that several CD4 mAbs may delay allograft rejection in the absence of circulating CD4+ lymphocyte depletion in vivo, we investigated the mechanisms whereby CD4 mAbs can interfere with the development of alloreactive T cells in the mixed lymphocyte reaction (MLR). In agreement with previous r...

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Bibliographic Details
Main Authors: Fournel, S, Vincent, C, Assossou, O, Gorman, S, Robinet, E, Phillips, J, Flacher, M, Cordier, G, Waldmann, H, Revillard, J
Format: Journal article
Language:English
Published: 1996

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