Extracellular cation sensing by the enterocyte: prediction of a novel divalent cation "receptor".
We report that the divalent cation Ni2+ elicits elevations in the cytosolic free Ca2+ concentration ([Ca2+]) in cultured enterocytes. These elevations were monophasic, each response consisting of a rapid initial transient rise of cytosolic [Ca2+] to a peak value followed by an exponential decline. T...
| Κύριοι συγγραφείς: | , , , , , , |
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| Μορφή: | Journal article |
| Γλώσσα: | English |
| Έκδοση: |
1995
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| _version_ | 1826284931553165312 |
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| author | Pazianas, M Adebanjo, O Shankar, V James, S Colston, K Maxwell, J Zaidi, M |
| author_facet | Pazianas, M Adebanjo, O Shankar, V James, S Colston, K Maxwell, J Zaidi, M |
| author_sort | Pazianas, M |
| collection | OXFORD |
| description | We report that the divalent cation Ni2+ elicits elevations in the cytosolic free Ca2+ concentration ([Ca2+]) in cultured enterocytes. These elevations were monophasic, each response consisting of a rapid initial transient rise of cytosolic [Ca2+] to a peak value followed by an exponential decline. The magnitude of the cytosolic [Ca2+] elevation varied with the concentration of applied Ni2+. In some cells, a single application of Ni2+ induced oscillatory changes in cytosolic [Ca2+]. There was also evidence for use-dependent inactivation: a conditioning application of Ni2+ substantially attenuated the response resulting from its subsequent application. Our findings thus demonstrate the existence of a divalent cation-sensing "receptor" on the enterocyte. This putative receptor may play a role in regulating mineral absorption across the enterocyte membrane. |
| first_indexed | 2024-03-07T01:21:15Z |
| format | Journal article |
| id | oxford-uuid:906d63d2-f1c8-4e2e-9f1a-e9a31623285d |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T01:21:15Z |
| publishDate | 1995 |
| record_format | dspace |
| spelling | oxford-uuid:906d63d2-f1c8-4e2e-9f1a-e9a31623285d2022-03-26T23:11:27ZExtracellular cation sensing by the enterocyte: prediction of a novel divalent cation "receptor".Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:906d63d2-f1c8-4e2e-9f1a-e9a31623285dEnglishSymplectic Elements at Oxford1995Pazianas, MAdebanjo, OShankar, VJames, SColston, KMaxwell, JZaidi, MWe report that the divalent cation Ni2+ elicits elevations in the cytosolic free Ca2+ concentration ([Ca2+]) in cultured enterocytes. These elevations were monophasic, each response consisting of a rapid initial transient rise of cytosolic [Ca2+] to a peak value followed by an exponential decline. The magnitude of the cytosolic [Ca2+] elevation varied with the concentration of applied Ni2+. In some cells, a single application of Ni2+ induced oscillatory changes in cytosolic [Ca2+]. There was also evidence for use-dependent inactivation: a conditioning application of Ni2+ substantially attenuated the response resulting from its subsequent application. Our findings thus demonstrate the existence of a divalent cation-sensing "receptor" on the enterocyte. This putative receptor may play a role in regulating mineral absorption across the enterocyte membrane. |
| spellingShingle | Pazianas, M Adebanjo, O Shankar, V James, S Colston, K Maxwell, J Zaidi, M Extracellular cation sensing by the enterocyte: prediction of a novel divalent cation "receptor". |
| title | Extracellular cation sensing by the enterocyte: prediction of a novel divalent cation "receptor". |
| title_full | Extracellular cation sensing by the enterocyte: prediction of a novel divalent cation "receptor". |
| title_fullStr | Extracellular cation sensing by the enterocyte: prediction of a novel divalent cation "receptor". |
| title_full_unstemmed | Extracellular cation sensing by the enterocyte: prediction of a novel divalent cation "receptor". |
| title_short | Extracellular cation sensing by the enterocyte: prediction of a novel divalent cation "receptor". |
| title_sort | extracellular cation sensing by the enterocyte prediction of a novel divalent cation receptor |
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