Partial liquid ventilation with perfluorocarbon in the treatment of rats with lethal pneumococcal pneumonia.
BACKGROUND: Partial liquid ventilation with perfluorocarbon is a new therapeutic strategy to treat various lung disorders. The current study was undertaken to determine the efficacy of partial liquid ventilation with a perfluorocarbon (FC-77) in the treatment of pneumococcal pneumonia in rats. METHO...
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| Fformat: | Journal article |
| Iaith: | English |
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1998
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| _version_ | 1826284932338548736 |
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| author | Dickson, E Heard, S Chu, B Fraire, A Brueggemann, A Doern, G |
| author_facet | Dickson, E Heard, S Chu, B Fraire, A Brueggemann, A Doern, G |
| author_sort | Dickson, E |
| collection | OXFORD |
| description | BACKGROUND: Partial liquid ventilation with perfluorocarbon is a new therapeutic strategy to treat various lung disorders. The current study was undertaken to determine the efficacy of partial liquid ventilation with a perfluorocarbon (FC-77) in the treatment of pneumococcal pneumonia in rats. METHODS: Male Wistar rats (weight, 275-300 g; n, 75) were infected via direct intratracheal inoculation with ca 10(9) colony-forming units of viable Streptococcus pneumoniae, serotype 3, and 24 h after infection were placed into one of five groups, each containing 15 rats. The groups were (1) no treatment, (2) one intramuscular injection of penicillin G benzathine (200,000 U), (3) partial liquid ventilation with FC-77, (4) partial liquid ventilation with FC-77 and a single intramuscular dose of penicillin G benzathine (200,000 U), and (5) gas ventilation. Animals were observed every 24 h for survival. RESULTS: All untreated or gas-ventilated animals or animals that received only partial liquid ventilation were dead by 7 days. Those receiving only partial liquid ventilation survived longer than untreated controls, but ultimately all succumbed by day 7. Survival was 40% for penicillin-treated rats compared with controls (P < 0.05) and 80% for animals treated with both partial liquid ventilation and penicillin versus antibiotic alone (P < 0.05). CONCLUSIONS: These observations suggest that partial liquid ventilation with perfluorocarbon in combination with antibiotic administration may be an effective therapeutic modality in pneumococcal pneumonia. |
| first_indexed | 2024-03-07T01:21:16Z |
| format | Journal article |
| id | oxford-uuid:906dcebd-b0bd-4f18-bffd-e511057dd4ed |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T01:21:16Z |
| publishDate | 1998 |
| record_format | dspace |
| spelling | oxford-uuid:906dcebd-b0bd-4f18-bffd-e511057dd4ed2022-03-26T23:11:28ZPartial liquid ventilation with perfluorocarbon in the treatment of rats with lethal pneumococcal pneumonia.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:906dcebd-b0bd-4f18-bffd-e511057dd4edEnglishSymplectic Elements at Oxford1998Dickson, EHeard, SChu, BFraire, ABrueggemann, ADoern, GBACKGROUND: Partial liquid ventilation with perfluorocarbon is a new therapeutic strategy to treat various lung disorders. The current study was undertaken to determine the efficacy of partial liquid ventilation with a perfluorocarbon (FC-77) in the treatment of pneumococcal pneumonia in rats. METHODS: Male Wistar rats (weight, 275-300 g; n, 75) were infected via direct intratracheal inoculation with ca 10(9) colony-forming units of viable Streptococcus pneumoniae, serotype 3, and 24 h after infection were placed into one of five groups, each containing 15 rats. The groups were (1) no treatment, (2) one intramuscular injection of penicillin G benzathine (200,000 U), (3) partial liquid ventilation with FC-77, (4) partial liquid ventilation with FC-77 and a single intramuscular dose of penicillin G benzathine (200,000 U), and (5) gas ventilation. Animals were observed every 24 h for survival. RESULTS: All untreated or gas-ventilated animals or animals that received only partial liquid ventilation were dead by 7 days. Those receiving only partial liquid ventilation survived longer than untreated controls, but ultimately all succumbed by day 7. Survival was 40% for penicillin-treated rats compared with controls (P < 0.05) and 80% for animals treated with both partial liquid ventilation and penicillin versus antibiotic alone (P < 0.05). CONCLUSIONS: These observations suggest that partial liquid ventilation with perfluorocarbon in combination with antibiotic administration may be an effective therapeutic modality in pneumococcal pneumonia. |
| spellingShingle | Dickson, E Heard, S Chu, B Fraire, A Brueggemann, A Doern, G Partial liquid ventilation with perfluorocarbon in the treatment of rats with lethal pneumococcal pneumonia. |
| title | Partial liquid ventilation with perfluorocarbon in the treatment of rats with lethal pneumococcal pneumonia. |
| title_full | Partial liquid ventilation with perfluorocarbon in the treatment of rats with lethal pneumococcal pneumonia. |
| title_fullStr | Partial liquid ventilation with perfluorocarbon in the treatment of rats with lethal pneumococcal pneumonia. |
| title_full_unstemmed | Partial liquid ventilation with perfluorocarbon in the treatment of rats with lethal pneumococcal pneumonia. |
| title_short | Partial liquid ventilation with perfluorocarbon in the treatment of rats with lethal pneumococcal pneumonia. |
| title_sort | partial liquid ventilation with perfluorocarbon in the treatment of rats with lethal pneumococcal pneumonia |
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