Why inhibitors of mammalian target of rapamycin will be important in organ transplantation

Why inhibitors of mammalian target of rapamycin will be important in organ transplantation

Drugs using inhibitors of mammalian target of rapamycin provide a real opportunity to treat patients with much lower exposure to calcineurin inhibitors. Long-term studies remain to be completed that show whether this might lead to important reductions in drug-related kidney damage. Evidence is start...

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Bibliographic Details
Main Authors: Brockmann, J, Friend, P
Format: Journal article
Language:English
Published: 2004
Description
Summary:Drugs using inhibitors of mammalian target of rapamycin provide a real opportunity to treat patients with much lower exposure to calcineurin inhibitors. Long-term studies remain to be completed that show whether this might lead to important reductions in drug-related kidney damage. Evidence is starting to accumulate that the use of a mammalian target of rapamycin inhibitor early after transplantation might be contraindicated because of impairment in tubular regeneration. © 2004 Lippincott Williams and Wilkins.

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