Synthesis and reactivity of novel γ-phosphate modified ATP analogues

Synthesis and reactivity of novel γ-phosphate modified ATP analogues

We hereby present a simple yet novel chemical synthesis of a family of γ-modified ATPs bearing functional groups on the γ-phosphate that are amenable to further derivatization by highly selective chemical manipulations (e.g., click chemistry, Staudinger ligations). A preliminary screen of these comp...

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Библиографические подробности
Главные авторы: Lee, SE, Elphick, L, Anderson, A, Bonnac, L, Child, E, Mann, D, Gouverneur, V
Формат: Journal article
Язык:English
Опубликовано: 2009
Описание
Итог:We hereby present a simple yet novel chemical synthesis of a family of γ-modified ATPs bearing functional groups on the γ-phosphate that are amenable to further derivatization by highly selective chemical manipulations (e.g., click chemistry, Staudinger ligations). A preliminary screen of these compounds as phosphate donors with a typical wild type protein kinase (cdk2) and one of its known substrates p27kip1 is also presented. © 2009 Elsevier Ltd. All rights reserved.

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