Synthesis of modified proteins via functionalization of dehydroalanine
Dehydroalanine has emerged in recent years as a non-proteinogenic residue with strong chemical utility in proteins for the study of biology. In this review we cover the several methods now available for its flexible and site-selective incorporation via a variety of complementary chemical and biologi...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
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Elsevier
2018
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| _version_ | 1826284954455113728 |
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| author | Dadová, J Galan, S Davis, B |
| author_facet | Dadová, J Galan, S Davis, B |
| author_sort | Dadová, J |
| collection | OXFORD |
| description | Dehydroalanine has emerged in recent years as a non-proteinogenic residue with strong chemical utility in proteins for the study of biology. In this review we cover the several methods now available for its flexible and site-selective incorporation via a variety of complementary chemical and biological techniques and examine its reactivity, allowing both creation of modified protein side-chains through a variety of bond-forming methods (C-S, C-N, C-Se, C-C) and as an activity-based probe in its own right. We illustrate its utility with selected examples of biological and technological discovery and application. |
| first_indexed | 2024-03-07T01:21:36Z |
| format | Journal article |
| id | oxford-uuid:90893143-96c8-4f50-ad6b-b0086ca00737 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T01:21:36Z |
| publishDate | 2018 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | oxford-uuid:90893143-96c8-4f50-ad6b-b0086ca007372022-03-26T23:12:18ZSynthesis of modified proteins via functionalization of dehydroalanineJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:90893143-96c8-4f50-ad6b-b0086ca00737EnglishSymplectic Elements at OxfordElsevier2018Dadová, JGalan, SDavis, BDehydroalanine has emerged in recent years as a non-proteinogenic residue with strong chemical utility in proteins for the study of biology. In this review we cover the several methods now available for its flexible and site-selective incorporation via a variety of complementary chemical and biological techniques and examine its reactivity, allowing both creation of modified protein side-chains through a variety of bond-forming methods (C-S, C-N, C-Se, C-C) and as an activity-based probe in its own right. We illustrate its utility with selected examples of biological and technological discovery and application. |
| spellingShingle | Dadová, J Galan, S Davis, B Synthesis of modified proteins via functionalization of dehydroalanine |
| title | Synthesis of modified proteins via functionalization of dehydroalanine |
| title_full | Synthesis of modified proteins via functionalization of dehydroalanine |
| title_fullStr | Synthesis of modified proteins via functionalization of dehydroalanine |
| title_full_unstemmed | Synthesis of modified proteins via functionalization of dehydroalanine |
| title_short | Synthesis of modified proteins via functionalization of dehydroalanine |
| title_sort | synthesis of modified proteins via functionalization of dehydroalanine |
| work_keys_str_mv | AT dadovaj synthesisofmodifiedproteinsviafunctionalizationofdehydroalanine AT galans synthesisofmodifiedproteinsviafunctionalizationofdehydroalanine AT davisb synthesisofmodifiedproteinsviafunctionalizationofdehydroalanine |