Combined anti-inflammatory and neuroprotective treatments have the potential to impact disease phenotypes in Cln3 -/- mice

Combined anti-inflammatory and neuroprotective treatments have the potential to impact disease phenotypes in Cln3 -/- mice

Batten disease, or juvenile NCL, is a fatal neurodegenerative disorder that occurs due to mutations in the CLN3 gene. Because the function of CLN3 remains unclear, experimental therapies for JNCL have largely concentrated upon the targeting of downstream pathomechanisms. Neuron loss is preceded by l...

Disgrifiad llawn

Manylion Llyfryddiaeth
Prif Awduron:	Tarczyluk-Wells, M, Salzlechner, C, Najafi, A, Lim, M, Smith, D, Platt, F, Williams, B, Cooper, J
Fformat:	Journal article
Iaith:	English
Cyhoeddwyd:	2019

Eitemau Tebyg

Combined Anti-inflammatory and Neuroprotective Treatments Have the Potential to Impact Disease Phenotypes in Cln3−/− Mice
gan: Marta A. Tarczyluk-Wells, et al.
Cyhoeddwyd: (2019-09-01)

Phenotypic variant of CLN3 mutation
gan: Avinash Honasoge, et al.
Cyhoeddwyd: (2022-09-01)

Repurposing of tamoxifen ameliorates CLN3 and CLN7 disease phenotype
gan: Chiara Soldati, et al.
Cyhoeddwyd: (2021-08-01)

Exacerbated neuronal ceroid lipofuscinosis phenotype in Cln1/5 double-knockout mice
gan: Tea Blom, et al.
Cyhoeddwyd: (2013-03-01)

Invited editorial in regards to phenotypic variant of CLN3 mutation
gan: Avinash Honasoge, et al.
Cyhoeddwyd: (2023-03-01)

Anti-inflammatory treatment with acetylsalicylate or rofecoxib is not neuroprotective in Huntington's disease transgenic mice
gan: Fran Norflus, et al.
Cyhoeddwyd: (2004-11-01)

Beige adipocytes mediate the neuroprotective and anti-inflammatory effects of subcutaneous fat in obese mice
gan: De-Huang Guo, et al.
Cyhoeddwyd: (2021-07-01)

CLN6‐related continuum phenotype caused by aberrant splicing
gan: Federica Invernizzi, et al.
Cyhoeddwyd: (2025-02-01)

Brain gene expression profiles of <it>Cln1 </it>and <it>Cln5 </it>deficient mice unravels common molecular pathways underlying neuronal degeneration in NCL diseases
gan: Gentile Massimiliano, et al.
Cyhoeddwyd: (2008-03-01)

An altered transcriptome underlies cln5-deficiency phenotypes in Dictyostelium discoideum
gan: William D. Kim, et al.
Cyhoeddwyd: (2022-11-01)

Data on characterizing the gene expression patterns of neuronal ceroid lipofuscinosis genes: CLN1, CLN2, CLN3, CLN5 and their association to interneuron and neurotransmission markers: Parvalbumin and Somatostatin
gan: Helena M. Minye, et al.
Cyhoeddwyd: (2016-09-01)

Luteolin triggers global changes in the microglial transcriptome leading to a unique anti-inflammatory and neuroprotective phenotype
gan: Moehle Christoph, et al.
Cyhoeddwyd: (2010-01-01)

Phytochemicals from <i>Passiflora coriacea</i> Juss. Have Anti-Inflammatory and Neuroprotective Effects in Mouse Models
gan: Samir Castolo-Sanchez, et al.
Cyhoeddwyd: (2024-11-01)

Correction: Luteolin triggers global changes in the microglial transcriptome leading to a unique anti-inflammatory and neuroprotective phenotype
gan: Dirscherl Konstantin, et al.
Cyhoeddwyd: (2012-06-01)

Mechanism of Siponimod: Anti-Inflammatory and Neuroprotective Mode of Action
gan: Newshan Behrangi, et al.
Cyhoeddwyd: (2019-01-01)

A novel porcine model of CLN3 Batten disease recapitulates clinical phenotypes
gan: Vicki J. Swier, et al.
Cyhoeddwyd: (2023-08-01)

Targeting autophagy impairment improves the phenotype of a novel CLN8 zebrafish model
gan: Maria Marchese, et al.
Cyhoeddwyd: (2024-07-01)

Cross-species efficacy of enzyme replacement therapy for CLN1 disease in mice and sheep
gan: Hemanth R. Nelvagal, et al.
Cyhoeddwyd: (2022-10-01)

Cln5-deficiency in mice leads to microglial activation, defective myelination and changes in lipid metabolism
gan: Mia-Lisa Schmiedt, et al.
Cyhoeddwyd: (2012-04-01)

Gene expression profiling in brain of mice exposed to the marine neurotoxin ciguatoxin reveals an acute anti-inflammatory, neuroprotective response
gan: Ryan James C, et al.
Cyhoeddwyd: (2010-08-01)

Neuroprotective Effect of Catalpol via Anti-Oxidative, Anti-Inflammatory, and Anti-Apoptotic Mechanisms
gan: Chunjing Yang, et al.
Cyhoeddwyd: (2020-05-01)

Neuroprotective and Anti-inflammatory Effects of Pioglitazone on Traumatic Brain Injury
gan: Mohammad Yassin Zamanian, et al.
Cyhoeddwyd: (2022-01-01)

Structural Requirements for the Neuroprotective and Anti-Inflammatory Activities of the Flavanone Sterubin
gan: Zhibin Liang, et al.
Cyhoeddwyd: (2022-11-01)

Improved neuroprotection using miglustat, curcumin and ibuprofen as a triple combination therapy in Niemann–Pick disease type C1 mice
gan: Ian M. Williams, et al.
Cyhoeddwyd: (2014-07-01)

Electroretinography data from ovine models of CLN5 and CLN6 neuronal ceroid lipofuscinoses
gan: Katharina N. Russell, et al.
Cyhoeddwyd: (2021-08-01)

Glycerophosphoinositol is Elevated in Blood Samples From pigs, Mice, and CLN3-Affected Individuals
gan: Jon J Brudvig, et al.
Cyhoeddwyd: (2022-06-01)

TRPML1 activation ameliorates lysosomal phenotypes in CLN3 deficient retinal pigment epithelial cells
gan: D. Wünkhaus, et al.
Cyhoeddwyd: (2024-07-01)

Combined anti-inflammatory and anti-AGE drug treatments have a protective effect on intervertebral discs in mice with diabetes.
gan: Svenja Illien-Junger, et al.
Cyhoeddwyd: (2013-01-01)

in vivo localization of the neuronal ceroid lipofuscinosis proteins, CLN3 and CLN7, at endogenous expression levels
gan: Alamin Mohammed, et al.
Cyhoeddwyd: (2017-07-01)

Loss of Cln5 leads to altered Gad1 expression and deficits in interneuron development in mice
gan: Singh, Y, et al.
Cyhoeddwyd: (2019)

Sex- and region-biased depletion of microglia/macrophages attenuates CLN1 disease in mice
gan: Kristina Berve, et al.
Cyhoeddwyd: (2020-10-01)

An anti-inflammatory and neuroprotective biomimetic nanoplatform for repairing spinal cord injury
gan: Xiang Gao, et al.
Cyhoeddwyd: (2022-12-01)

The Antioxidant, Anti-Inflammatory, and Neuroprotective Properties of the Synthetic Chalcone Derivative AN07
gan: Yih-Fung Chen, et al.
Cyhoeddwyd: (2020-06-01)

Characterisation of early changes in ovine CLN5 and CLN6 Batten disease neural cultures for the rapid screening of therapeutics
gan: Hannah L Best, et al.
Cyhoeddwyd: (2017-04-01)

An Unusual Presentation of Neuronal Ceroid Lipofuscinosis With CLN6 Mutation
gan: Shahin Koohmanaee, et al.
Cyhoeddwyd: (2023-01-01)

Sex-split analysis of pathology and motor-behavioral outcomes in a mouse model of CLN8-Batten disease reveals an increased disease burden and trajectory in female Cln8 mnd mice
gan: Andrew D. Holmes, et al.
Cyhoeddwyd: (2022-11-01)

Physiotherapy for Children with CLN2 Disease
gan: Ina von Löbbecke
Cyhoeddwyd: (2019-11-01)

Progressive thalamocortical neuron loss in Cln5 deficient mice: Distinct effects in Finnish variant late infantile NCL
gan: Carina von Schantz, et al.
Cyhoeddwyd: (2009-05-01)

Annexin A1: a central player in the anti-inflammatory and neuroprotective role of microglia.
gan: McArthur, S, et al.
Cyhoeddwyd: (2010)

Gene disruption of Mfsd8 in mice provides the first animal model for CLN7 disease
gan: Markus Damme, et al.
Cyhoeddwyd: (2014-05-01)