Combined anti-inflammatory and neuroprotective treatments have the potential to impact disease phenotypes in Cln3 -/- mice

Combined anti-inflammatory and neuroprotective treatments have the potential to impact disease phenotypes in Cln3 -/- mice

Batten disease, or juvenile NCL, is a fatal neurodegenerative disorder that occurs due to mutations in the CLN3 gene. Because the function of CLN3 remains unclear, experimental therapies for JNCL have largely concentrated upon the targeting of downstream pathomechanisms. Neuron loss is preceded by l...

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Bibliografiske detaljer
Main Authors:	Tarczyluk-Wells, M, Salzlechner, C, Najafi, A, Lim, M, Smith, D, Platt, F, Williams, B, Cooper, J
Format:	Journal article
Sprog:	English
Udgivet:	2019

Lignende værker

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af: Chiara Soldati, et al.
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af: Tea Blom, et al.
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af: Avinash Honasoge, et al.
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Anti-inflammatory treatment with acetylsalicylate or rofecoxib is not neuroprotective in Huntington's disease transgenic mice
af: Fran Norflus, et al.
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af: De-Huang Guo, et al.
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af: Gentile Massimiliano, et al.
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af: William D. Kim, et al.
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Data on characterizing the gene expression patterns of neuronal ceroid lipofuscinosis genes: CLN1, CLN2, CLN3, CLN5 and their association to interneuron and neurotransmission markers: Parvalbumin and Somatostatin
af: Helena M. Minye, et al.
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af: Moehle Christoph, et al.
Udgivet: (2010-01-01)

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af: Dirscherl Konstantin, et al.
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af: Newshan Behrangi, et al.
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af: Vicki J. Swier, et al.
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af: Mia-Lisa Schmiedt, et al.
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af: Ryan James C, et al.
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af: Chunjing Yang, et al.
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af: Mohammad Yassin Zamanian, et al.
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af: Zhibin Liang, et al.
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af: Ian M. Williams, et al.
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Electroretinography data from ovine models of CLN5 and CLN6 neuronal ceroid lipofuscinoses
af: Katharina N. Russell, et al.
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af: Jon J Brudvig, et al.
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af: D. Wünkhaus, et al.
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af: Svenja Illien-Junger, et al.
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af: Alamin Mohammed, et al.
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