Combined anti-inflammatory and neuroprotective treatments have the potential to impact disease phenotypes in Cln3 -/- mice

Combined anti-inflammatory and neuroprotective treatments have the potential to impact disease phenotypes in Cln3 -/- mice

Batten disease, or juvenile NCL, is a fatal neurodegenerative disorder that occurs due to mutations in the CLN3 gene. Because the function of CLN3 remains unclear, experimental therapies for JNCL have largely concentrated upon the targeting of downstream pathomechanisms. Neuron loss is preceded by l...

書誌詳細
主要な著者:	Tarczyluk-Wells, M, Salzlechner, C, Najafi, A, Lim, M, Smith, D, Platt, F, Williams, B, Cooper, J
フォーマット:	Journal article
言語:	English
出版事項:	2019

類似資料

Combined Anti-inflammatory and Neuroprotective Treatments Have the Potential to Impact Disease Phenotypes in Cln3−/− Mice
著者:: Marta A. Tarczyluk-Wells, 等
出版事項: (2019-09-01)

Phenotypic variant of CLN3 mutation
著者:: Avinash Honasoge, 等
出版事項: (2022-09-01)

Repurposing of tamoxifen ameliorates CLN3 and CLN7 disease phenotype
著者:: Chiara Soldati, 等
出版事項: (2021-08-01)

Exacerbated neuronal ceroid lipofuscinosis phenotype in Cln1/5 double-knockout mice
著者:: Tea Blom, 等
出版事項: (2013-03-01)

Invited editorial in regards to phenotypic variant of CLN3 mutation
著者:: Avinash Honasoge, 等
出版事項: (2023-03-01)

Anti-inflammatory treatment with acetylsalicylate or rofecoxib is not neuroprotective in Huntington's disease transgenic mice
著者:: Fran Norflus, 等
出版事項: (2004-11-01)

Beige adipocytes mediate the neuroprotective and anti-inflammatory effects of subcutaneous fat in obese mice
著者:: De-Huang Guo, 等
出版事項: (2021-07-01)

CLN6‐related continuum phenotype caused by aberrant splicing
著者:: Federica Invernizzi, 等
出版事項: (2025-02-01)

Brain gene expression profiles of <it>Cln1 </it>and <it>Cln5 </it>deficient mice unravels common molecular pathways underlying neuronal degeneration in NCL diseases
著者:: Gentile Massimiliano, 等
出版事項: (2008-03-01)

An altered transcriptome underlies cln5-deficiency phenotypes in Dictyostelium discoideum
著者:: William D. Kim, 等
出版事項: (2022-11-01)

Data on characterizing the gene expression patterns of neuronal ceroid lipofuscinosis genes: CLN1, CLN2, CLN3, CLN5 and their association to interneuron and neurotransmission markers: Parvalbumin and Somatostatin
著者:: Helena M. Minye, 等
出版事項: (2016-09-01)

Luteolin triggers global changes in the microglial transcriptome leading to a unique anti-inflammatory and neuroprotective phenotype
著者:: Moehle Christoph, 等
出版事項: (2010-01-01)

Phytochemicals from <i>Passiflora coriacea</i> Juss. Have Anti-Inflammatory and Neuroprotective Effects in Mouse Models
著者:: Samir Castolo-Sanchez, 等
出版事項: (2024-11-01)

Correction: Luteolin triggers global changes in the microglial transcriptome leading to a unique anti-inflammatory and neuroprotective phenotype
著者:: Dirscherl Konstantin, 等
出版事項: (2012-06-01)

Mechanism of Siponimod: Anti-Inflammatory and Neuroprotective Mode of Action
著者:: Newshan Behrangi, 等
出版事項: (2019-01-01)

A novel porcine model of CLN3 Batten disease recapitulates clinical phenotypes
著者:: Vicki J. Swier, 等
出版事項: (2023-08-01)

Targeting autophagy impairment improves the phenotype of a novel CLN8 zebrafish model
著者:: Maria Marchese, 等
出版事項: (2024-07-01)

Cross-species efficacy of enzyme replacement therapy for CLN1 disease in mice and sheep
著者:: Hemanth R. Nelvagal, 等
出版事項: (2022-10-01)

Cln5-deficiency in mice leads to microglial activation, defective myelination and changes in lipid metabolism
著者:: Mia-Lisa Schmiedt, 等
出版事項: (2012-04-01)

Gene expression profiling in brain of mice exposed to the marine neurotoxin ciguatoxin reveals an acute anti-inflammatory, neuroprotective response
著者:: Ryan James C, 等
出版事項: (2010-08-01)

Neuroprotective Effect of Catalpol via Anti-Oxidative, Anti-Inflammatory, and Anti-Apoptotic Mechanisms
著者:: Chunjing Yang, 等
出版事項: (2020-05-01)

Neuroprotective and Anti-inflammatory Effects of Pioglitazone on Traumatic Brain Injury
著者:: Mohammad Yassin Zamanian, 等
出版事項: (2022-01-01)

Structural Requirements for the Neuroprotective and Anti-Inflammatory Activities of the Flavanone Sterubin
著者:: Zhibin Liang, 等
出版事項: (2022-11-01)

Improved neuroprotection using miglustat, curcumin and ibuprofen as a triple combination therapy in Niemann–Pick disease type C1 mice
著者:: Ian M. Williams, 等
出版事項: (2014-07-01)

Electroretinography data from ovine models of CLN5 and CLN6 neuronal ceroid lipofuscinoses
著者:: Katharina N. Russell, 等
出版事項: (2021-08-01)

Glycerophosphoinositol is Elevated in Blood Samples From pigs, Mice, and CLN3-Affected Individuals
著者:: Jon J Brudvig, 等
出版事項: (2022-06-01)

TRPML1 activation ameliorates lysosomal phenotypes in CLN3 deficient retinal pigment epithelial cells
著者:: D. Wünkhaus, 等
出版事項: (2024-07-01)

Combined anti-inflammatory and anti-AGE drug treatments have a protective effect on intervertebral discs in mice with diabetes.
著者:: Svenja Illien-Junger, 等
出版事項: (2013-01-01)

in vivo localization of the neuronal ceroid lipofuscinosis proteins, CLN3 and CLN7, at endogenous expression levels
著者:: Alamin Mohammed, 等
出版事項: (2017-07-01)

Loss of Cln5 leads to altered Gad1 expression and deficits in interneuron development in mice
著者:: Singh, Y, 等
出版事項: (2019)

Sex- and region-biased depletion of microglia/macrophages attenuates CLN1 disease in mice
著者:: Kristina Berve, 等
出版事項: (2020-10-01)

An anti-inflammatory and neuroprotective biomimetic nanoplatform for repairing spinal cord injury
著者:: Xiang Gao, 等
出版事項: (2022-12-01)

The Antioxidant, Anti-Inflammatory, and Neuroprotective Properties of the Synthetic Chalcone Derivative AN07
著者:: Yih-Fung Chen, 等
出版事項: (2020-06-01)

Characterisation of early changes in ovine CLN5 and CLN6 Batten disease neural cultures for the rapid screening of therapeutics
著者:: Hannah L Best, 等
出版事項: (2017-04-01)

An Unusual Presentation of Neuronal Ceroid Lipofuscinosis With CLN6 Mutation
著者:: Shahin Koohmanaee, 等
出版事項: (2023-01-01)

Sex-split analysis of pathology and motor-behavioral outcomes in a mouse model of CLN8-Batten disease reveals an increased disease burden and trajectory in female Cln8 mnd mice
著者:: Andrew D. Holmes, 等
出版事項: (2022-11-01)

Physiotherapy for Children with CLN2 Disease
著者:: Ina von Löbbecke
出版事項: (2019-11-01)

Progressive thalamocortical neuron loss in Cln5 deficient mice: Distinct effects in Finnish variant late infantile NCL
著者:: Carina von Schantz, 等
出版事項: (2009-05-01)

Annexin A1: a central player in the anti-inflammatory and neuroprotective role of microglia.
著者:: McArthur, S, 等
出版事項: (2010)

Gene disruption of Mfsd8 in mice provides the first animal model for CLN7 disease
著者:: Markus Damme, 等
出版事項: (2014-05-01)