Sialic acid transport in Haemophilus influenzae is essential for lipopolysaccharide sialylation and serum resistance and is dependent on a novel tripartite ATP-independent periplasmic transporter.

Sialic acid transport in Haemophilus influenzae is essential for lipopolysaccharide sialylation and serum resistance and is dependent on a novel tripartite ATP-independent periplasmic transporter.

Sialylation of the lipopolysaccharide (LPS) is an important mechanism used by the human pathogen Haemophilus influenzae to evade the innate immune response of the host. We have demonstrated that N-acetylneuraminic acid (Neu5Ac or sialic acid) uptake in H. influenzae is essential for the subsequent m...

Полное описание

Библиографические подробности
Главные авторы:	Severi, E, Randle, G, Kivlin, P, Whitfield, K, Young, R, Moxon, R, Kelly, D, Hood, D, Thomas, G
Формат:	Journal article
Язык:	English
Опубликовано:	2005

Схожие документы

Structural and biophysical analysis of a Haemophilus influenzae tripartite ATP-independent periplasmic (TRAP) transporter
по: Michael J Currie, и др.
Опубликовано: (2024-02-01)

Structure and mechanism of a tripartite ATP-independent periplasmic TRAP transporter
по: James S. Davies, и др.
Опубликовано: (2023-02-01)

Tripartite ATP-Independent Periplasmic (TRAP) Transporters and Tripartite Tricarboxylate Transporters (TTT): From Uptake to Pathogenicity
по: Leonardo T. Rosa, и др.
Опубликовано: (2018-02-01)

Structural and mechanistic analysis of a tripartite ATP-independent periplasmic TRAP transporter
по: Martin F. Peter, и др.
Опубликовано: (2022-08-01)

Host-derived sialic acid is incorporated into Haemophilus influenzae lipopolysaccharide and is a major virulence factor in experimental otitis media.
по: Bouchet, V, и др.
Опубликовано: (2003)

Sialic acid in the lipopolysaccharide of Haemophilus influenzae: strain distribution, influence on serum resistance and structural characterization.
по: Hood, D, и др.
Опубликовано: (1999)

Molecular determinants of Neu5Ac binding to a tripartite ATP independent periplasmic (TRAP) transporter
по: Parveen Goyal, и др.
Опубликовано: (2025-02-01)

Identification and structural characterization of a sialylated lacto-N-neotetraose structure in the lipopolysaccharide of Haemophilus influenzae.
по: Cox, A, и др.
Опубликовано: (2002)

Haemophilus influenzae lipopolysaccharide.
по: Hood, D, и др.
Опубликовано: (1999)

Bacterial lipopolysaccharides: candidate vaccines to prevent Neisseria meningitidis and Haemophilus influenzae infections.
по: Moxon, E, и др.
Опубликовано: (1998)

Over Expression of the CMP-sialic Acid Transporter in Chinese Hamster Ovary Cells Leads to Increased Sialylation
по: Wong, Niki S.C., и др.
Опубликовано: (2004)

lpt6, a gene required for addition of phosphoethanolamine to inner-core lipopolysaccharide of Neisseria meningitidis and Haemophilus influenzae.
по: Wright, J, и др.
Опубликовано: (2004)

Biosynthesis of cryptic lipopolysaccharide glycoforms in Haemophilus influenzae involves a mechanism similar to that required for O-antigen synthesis.
по: Hood, D, и др.
Опубликовано: (2004)

Sialic acid mediated transcriptional modulation of a highly conserved sialometabolism gene cluster in Haemophilus influenzae and its effect on virulence
по: Jenkins, G, и др.
Опубликовано: (2010)

Sialic acid utilization by bacterial pathogens.
по: Severi, E, и др.
Опубликовано: (2007)

Digalactoside expression in the lipopolysaccharide of Haemophilus influenzae and its role in intravascular survival.
по: Griffin, R, и др.
Опубликовано: (2005)

Structural analysis of the lipopolysaccharide from nontypeable Haemophilus influenzae strain R2846.
по: Lundström, S, и др.
Опубликовано: (2008)

Characterization of novel structural features in the lipopolysaccharide of nondisease associated nontypeable Haemophilus influenzae.
по: Landerholm, M, и др.
Опубликовано: (2004)

Structural analysis of lipopolysaccharides from Haemophilus influenzae serotype f. Structural diversity observed in three strains.
по: Yildirim, H, и др.
Опубликовано: (2003)

The role of lex2 in lipopolysaccharide biosynthesis in Haemophilus influenzae strains RM7004 and RM153
по: Griffin, R, и др.
Опубликовано: (2003)

Expression of a new disialyllacto structure in the lipopolysaccharide of non-typeable Haemophilus influenzae.
по: Twelkmeyer, B, и др.
Опубликовано: (2011)

Structural and genetic characterisation of variant glycoforms of Haemophilus influenzae lipopolysaccharide; implications for virulence
по: Schweda, E, и др.
Опубликовано: (2010)

Expression of a new disialyllacto structure in the lipopolysaccharide of non-typeable Haemophilus influenzae
по: Twelkmeyer, B, и др.
Опубликовано: (2011)

Sialic acid transport and catabolism are cooperatively regulated by SiaR and CRP in nontypeable <it>Haemophilus influenzae</it>
по: Johnston Jason W, и др.
Опубликовано: (2010-09-01)

Architecture and roles of periplasmic adaptor proteins in tripartite efflux assemblies.
по: Vassiliy N. Bavro, и др.
Опубликовано: (2015-05-01)

Biological function of sialic acid and sialylation in human health and disease
по: Wengen Zhu, и др.
Опубликовано: (2024-09-01)

An Engineered Pathway for Production of Terminally Sialylated N-glycoproteins in the Periplasm of Escherichia coli
по: Jing Zhu, и др.
Опубликовано: (2020-04-01)

Genes required for the synthesis of heptose-containing oligosaccharide outer core extensions in Haemophilus influenzae lipopolysaccharide.
по: Hood, D, и др.
Опубликовано: (2010)

Structural characterization of sialylated glycoforms of H. influenzae by electrospray mass spectrometry: fragmentation of protonated and sodiated O-deacylated lipopolysaccharides.
по: Li, J, и др.
Опубликовано: (2007)

The identification a novel gene required for lipopolysaccharide biosynthesis by Haemophilus influenzae RM7004, using transposon Tn916 mutagenesis.
по: High, N, и др.
Опубликовано: (1996)

Identification of a bifunctional lipopolysaccharide sialyltransferase in Haemophilus influenzae: incorporation of disialic acid.
по: Fox, K, и др.
Опубликовано: (2006)

The Lipopolysaccharide of Haemophilus parainfluenzae
по: Young, R
Опубликовано: (2011)

Structural studies of the lipopolysaccharide from Haemophilus parainfluenzae strain 20.
по: Vitiazeva, V, и др.
Опубликовано: (2011)

Use of the complete genome sequence information of Haemophilus influenzae strain Rd to investigate lipopolysaccharide biosynthesis.
по: Hood, D, и др.
Опубликовано: (1996)

Duplicate copies of lic1 direct the addition of multiple phosphocholine residues in the lipopolysaccharide of Haemophilus influenzae.
по: Fox, K, и др.
Опубликовано: (2008)

Glycoengineering of Darbepoetin-α in CHO-DG44 Cells through Overexpression of α-2,3-sialyl-transferase and CMP-sialic Acid Transporter
по: Adi Santoso, и др.
Опубликовано: (2022-01-01)

Sialic acid mediated transcriptional modulation of a highly conserved sialometabolism gene cluster in <it>Haemophilus influenzae </it>and its effect on virulence
по: Moxon Richard, и др.
Опубликовано: (2010-02-01)

Periplasmic depolymerase provides insight into ABC transporter-dependent secretion of bacterial capsular polysaccharides
по: Liston, SD, и др.
Опубликовано: (2018)

Novel lipopolysaccharide biosynthetic genes containing tetranucleotide repeats in Haemophilus influenzae, identification of a gene for adding O-acetyl groups.
по: Fox, K, и др.
Опубликовано: (2005)

Identification of a lipopolysaccharide alpha-2,3-sialyltransferase from Haemophilus influenzae.
по: Hood, D, и др.
Опубликовано: (2001)