Parameterised approximation of the fixation probability of the dominant mutation in the multi-type Moran process

<p>The multi-type Moran process is an evolutionary process on a connected graph&nbsp;<em>G</em>&nbsp;in which each vertex has one of&nbsp;<em>k</em>&nbsp;types and, in each step, a vertex&nbsp;<em>v</em>&nbsp;is chosen to reproduce it...

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Príomhchruthaitheoirí: Goldberg, LA, Roth, M, Schwarz, T
Formáid: Journal article
Teanga:English
Foilsithe / Cruthaithe: Elsevier 2024
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Achoimre:<p>The multi-type Moran process is an evolutionary process on a connected graph&nbsp;<em>G</em>&nbsp;in which each vertex has one of&nbsp;<em>k</em>&nbsp;types and, in each step, a vertex&nbsp;<em>v</em>&nbsp;is chosen to reproduce its type to one of its neighbours. The probability of a vertex&nbsp;<em>v</em>&nbsp;being chosen for reproduction is proportional to the fitness of the type of&nbsp;<em>v</em>. So far, the literature was almost solely concerned with the 2-type Moran process in which each vertex is either healthy (type 0) or a mutant (type 1), and the main problem of interest has been the (approximate) computation of the so-called&nbsp;<em>fixation probability</em>, i.e., the probability that eventually all vertices are mutants.</p> <p>In this work we initiate the study of approximating fixation probabilities in the multi-type Moran process on general graphs. Our main result is an FPTRAS (fixed-parameter tractable randomised approximation scheme) for computing the fixation probability of the dominant mutation; the parameter is the number of types and their fitnesses. In the course of our studies we also provide novel upper bounds on the expected&nbsp;<em>absorption time</em>, i.e., the time that it takes the multi-type Moran process to reach a state in which each vertex has the same type.</p>