Clonal expansions in acute EBV infection are detectable in the CD8 and not the CD4 subset and persist with a variable CD45 phenotype.

Clonal expansions in acute EBV infection are detectable in the CD8 and not the CD4 subset and persist with a variable CD45 phenotype.

We have applied a sensitive global analysis of TCR heterogeneity to compare clonal dynamics of CD4(+) and CD8(+) T cells in acute infectious mononucleosis. Using this approach, we are able to identify a broad representation of the total virus-specific population without the bias of in vitro culture...

Полное описание

Библиографические подробности
Главные авторы:	Maini, M, Gudgeon, N, Wedderburn, L, Rickinson, AB, Beverley, P
Формат:	Journal article
Язык:	English
Опубликовано:	2000

Схожие документы

A re-evaluation of the frequency of CD8+ T cells specific for EBV in healthy virus carriers.
по: Tan, L, и др.
Опубликовано: (1999)

Large clonal expansions of CD8+ T cells in acute infectious mononucleosis.
по: Callan, M, и др.
Опубликовано: (1996)

Unique phenotypes and clonal expansions of human CD4 effector memory T cells re-expressing CD45RA
по: Yuan Tian, и др.
Опубликовано: (2017-11-01)

Proteome-wide analysis of CD8+ T cell responses to EBV reveals differences between primary and persistent infection.
по: Calum Forrest, и др.
Опубликовано: (2018-09-01)

Phenotypic changes associated with activation of CD45RA+ and CD45RO+ T cells.
по: Wallace, D, и др.
Опубликовано: (1990)

Functional subsets of T cells defined by isoforms of CD45.
по: Beverley, P, и др.
Опубликовано: (1992)

Lifespan of human lymphocyte subsets defined by CD45 isoforms.
по: Michie, C, и др.
Опубликовано: (1992)

Clonal CD8+ T Lymphocytic Proliferation and Karyotypical Abnormalities in an EBV Associated Hemophagocytic Lymphohistiocytosis
по: Jiehao Zhou, и др.
Опубликовано: (2015-01-01)

P802: CD70/CD27 SIGNALING PROMOTES THE EXPANSION OF CLONAL PLASMA CELL SUBSETS IN MULTIPLE MYELOMA
по: Stefan Forster, и др.
Опубликовано: (2023-08-01)

Functional analysis of human T cell subsets defined by CD45 isoform expression.
по: Beverley, P
Опубликовано: (1992)

CD45 and the thymus.
по: Beverley, P
Опубликовано: (1989)

HIV infection of CD45RA+ and CD45RO+ CD4+ T cells.
по: Helbert, MR, и др.
Опубликовано: (1997)

CD4(-)CD8alphaalpha subset of CD1d-restricted NKT cells controls T cell expansion.
по: Ho, L, и др.
Опубликовано: (2004)

Characterization of the CD4+ T cell response to Epstein-Barr virus during primary and persistent infection.
по: Amyes, E, и др.
Опубликовано: (2003)

A comparison of two techniques for the molecular tracking of specific T-cell responses; CD4+ human T-cell clones persist in a stable hierarchy but at a lower frequency than clones in the CD8+ population.
по: Maini, M, и др.
Опубликовано: (1998)

Differences in the regulation of CD4 and CD8 T-cell clones during immune responses.
по: Beverley, P, и др.
Опубликовано: (2000)

In vitro responses of human CD45R0brightRA- and CD45R0-RAbright T cell subsets and their relationship to memory and naive T cells.
по: Young, J, и др.
Опубликовано: (1997)

Differentiation of subsets of CD4+ and CD8+ T cells - Discussion
по: Fitch, F, и др.
Опубликовано: (1995)

Phenotypic diversity of the CD45 antigen and its relationship to function.
по: Beverley, P, и др.
Опубликовано: (1988)

The distribution of CD45R, CD29 and CD45RO (UCHL1) antigens in mature CD4 positive T-cell leukaemias.
по: Worner, I, и др.
Опубликовано: (1990)

CD45 in memory and disease.
по: Tchilian, E, и др.
Опубликовано: (2002)

CD45 in memory and disease
по: Tchilian, E, и др.
Опубликовано: (2002)

CD45RB Status of CD8+ T Cell Memory Defines T Cell Receptor Affinity and Persistence
по: Scott M. Krummey, и др.
Опубликовано: (2020-02-01)

Evidence for differential expression of CD45 isoforms by precursors for memory-dependent and independent cytotoxic responses: human CD8 memory CTLp selectively express CD45RO (UCHL1).
по: Merkenschlager, M, и др.
Опубликовано: (1989)

Expansion of HIV-1-specific CD28- CD45RA- CD8+ T cells in chronically HIV-1-infected individuals.
по: Tomiyama, H, и др.
Опубликовано: (2000)

Clonal expansion of CD4+CD8+ T cells in an adult patient with Mycoplasma pneumoniae-associated Erythema multiforme majus
по: Sarah M. Volkers, и др.
Опубликовано: (2021-02-01)

Virus-induced CD8+ T cell clonal expansion is associated with telomerase up-regulation and telomere length preservation: a mechanism for rescue from replicative senescence.
по: Maini, M, и др.
Опубликовано: (1999)

CD49a Identifies Polyfunctional Memory CD8 T Cell Subsets that Persist in the Lungs After Influenza Infection
по: Emma C. Reilly, и др.
Опубликовано: (2021-09-01)

Altered CD45 expression and disease
по: Tchilian, E, и др.
Опубликовано: (2006)

Altered CD45 expression and disease.
по: Tchilian, E, и др.
Опубликовано: (2006)

CD4+, CD8+ and CD4- CD8- T cell-subsets can confer protection against Leishmania m. mexicana infection
по: C. M Lezama-Dávila, и др.
Опубликовано: (1995-02-01)

EBV promotes human CD8 NKT cell development.
по: Yuling He, и др.
Опубликовано: (2010-05-01)

Phenotypic and functional evaluation of CD3+CD4−CD8− T cells in human CD8 immunodeficiency
по: Iván Bernardo, и др.
Опубликовано: (2011-08-01)

In vivo clonal expansion and phenotypes of hypocretin-specific CD4+ T cells in narcolepsy patients and controls
по: Wei Jiang, и др.
Опубликовано: (2019-11-01)

Osterix-Cre marks distinct subsets of CD45- and CD45+ stromal populations in extra-skeletal tumors with pro-tumorigenic characteristics
по: Biancamaria Ricci, и др.
Опубликовано: (2020-08-01)

Clonal populations of CD4+ and CD8+ T cells in patients with multiple myeloma and paraproteinemia.
по: Moss, P, и др.
Опубликовано: (1996)

Clonally diverse CD38+HLA-DR+CD8+ T cells persist during fatal H7N9 disease
по: Zhongfang Wang, и др.
Опубликовано: (2018-02-01)

Altered CD45 isoform expression affects lymphocyte function in CD45 Tg mice.
по: Tchilian, E, и др.
Опубликовано: (2004)

Retraction: EBV promotes human CD8 NKT cell development.
Опубликовано: (2010-12-01)

Exhausted phenotype of circulating CD8+ T cell subsets in hepatitis B virus carriers
по: Daixi Jiang, и др.
Опубликовано: (2022-04-01)