HIV-1 infection-induced apoptotic microparticles inhibit human DCs via CD44.
Acute HIV-1 infection results in dysregulated immunity, which contributes to poor control of viral infection. DCs are key regulators of both adaptive and innate immune responses needed for controlling HIV-1, and we surmised that factors elicited during acute HIV-1 infection might impede DC function....
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
2012
|
| _version_ | 1797082021711839232 |
|---|---|
| author | Frleta, D Ochoa, C Kramer, H Khan, SA Stacey, A Borrow, P Kessler, B Haynes, B Bhardwaj, N |
| author_facet | Frleta, D Ochoa, C Kramer, H Khan, SA Stacey, A Borrow, P Kessler, B Haynes, B Bhardwaj, N |
| author_sort | Frleta, D |
| collection | OXFORD |
| description | Acute HIV-1 infection results in dysregulated immunity, which contributes to poor control of viral infection. DCs are key regulators of both adaptive and innate immune responses needed for controlling HIV-1, and we surmised that factors elicited during acute HIV-1 infection might impede DC function. We derived immature DCs from healthy donor peripheral blood monocytes and treated them with plasma from uninfected control donors and donors with acute HIV-1 infections. We found that the plasma from patients with HIV specifically inhibited DC function. This suppression was mediated by elevated apoptotic microparticles derived from dying cells during acute HIV-1 infection. Apoptotic microparticles bound to and inhibited DCs through the hyaluronate receptor CD44. These data suggest that targeting this CD44-mediated inhibition by apoptotic microparticles could be a novel strategy to potentiate DC activation of HIV-specific immunity. |
| first_indexed | 2024-03-07T01:22:17Z |
| format | Journal article |
| id | oxford-uuid:90c33266-93a3-4546-afa8-a4e8e4e89334 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T01:22:17Z |
| publishDate | 2012 |
| record_format | dspace |
| spelling | oxford-uuid:90c33266-93a3-4546-afa8-a4e8e4e893342022-03-26T23:14:02ZHIV-1 infection-induced apoptotic microparticles inhibit human DCs via CD44.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:90c33266-93a3-4546-afa8-a4e8e4e89334EnglishSymplectic Elements at Oxford2012Frleta, DOchoa, CKramer, HKhan, SAStacey, ABorrow, PKessler, BHaynes, BBhardwaj, NAcute HIV-1 infection results in dysregulated immunity, which contributes to poor control of viral infection. DCs are key regulators of both adaptive and innate immune responses needed for controlling HIV-1, and we surmised that factors elicited during acute HIV-1 infection might impede DC function. We derived immature DCs from healthy donor peripheral blood monocytes and treated them with plasma from uninfected control donors and donors with acute HIV-1 infections. We found that the plasma from patients with HIV specifically inhibited DC function. This suppression was mediated by elevated apoptotic microparticles derived from dying cells during acute HIV-1 infection. Apoptotic microparticles bound to and inhibited DCs through the hyaluronate receptor CD44. These data suggest that targeting this CD44-mediated inhibition by apoptotic microparticles could be a novel strategy to potentiate DC activation of HIV-specific immunity. |
| spellingShingle | Frleta, D Ochoa, C Kramer, H Khan, SA Stacey, A Borrow, P Kessler, B Haynes, B Bhardwaj, N HIV-1 infection-induced apoptotic microparticles inhibit human DCs via CD44. |
| title | HIV-1 infection-induced apoptotic microparticles inhibit human DCs via CD44. |
| title_full | HIV-1 infection-induced apoptotic microparticles inhibit human DCs via CD44. |
| title_fullStr | HIV-1 infection-induced apoptotic microparticles inhibit human DCs via CD44. |
| title_full_unstemmed | HIV-1 infection-induced apoptotic microparticles inhibit human DCs via CD44. |
| title_short | HIV-1 infection-induced apoptotic microparticles inhibit human DCs via CD44. |
| title_sort | hiv 1 infection induced apoptotic microparticles inhibit human dcs via cd44 |
| work_keys_str_mv | AT frletad hiv1infectioninducedapoptoticmicroparticlesinhibithumandcsviacd44 AT ochoac hiv1infectioninducedapoptoticmicroparticlesinhibithumandcsviacd44 AT kramerh hiv1infectioninducedapoptoticmicroparticlesinhibithumandcsviacd44 AT khansa hiv1infectioninducedapoptoticmicroparticlesinhibithumandcsviacd44 AT staceya hiv1infectioninducedapoptoticmicroparticlesinhibithumandcsviacd44 AT borrowp hiv1infectioninducedapoptoticmicroparticlesinhibithumandcsviacd44 AT kesslerb hiv1infectioninducedapoptoticmicroparticlesinhibithumandcsviacd44 AT haynesb hiv1infectioninducedapoptoticmicroparticlesinhibithumandcsviacd44 AT bhardwajn hiv1infectioninducedapoptoticmicroparticlesinhibithumandcsviacd44 |