Inhibition of fucosyl transferase and fucosidase by a rigid bicyclic mimic of alpha-L-fucose

A rigid bicyclic analogue of α-L-fucose, prepared from a monoacetonide of L-gulonolactone in an overall yield of 36% without the need for column chromatography, is a potent inhibitor of fucosidases and a weak inhibitor of a fucosyl transferase.

গ্রন্থ-পঞ্জীর বিবরন
প্রধান লেখক: Beacham, A, Smelt, K, Biggadike, K, Britten, C, Hackett, L, Winchester, BG, Nash, R, Griffiths, R, Fleet, G
বিন্যাস: Journal article
ভাষা:English
প্রকাশিত: 1998
বিবরন
সংক্ষিপ্ত:A rigid bicyclic analogue of α-L-fucose, prepared from a monoacetonide of L-gulonolactone in an overall yield of 36% without the need for column chromatography, is a potent inhibitor of fucosidases and a weak inhibitor of a fucosyl transferase.