Mechanistic and structural studies of KDM‐catalysed demethylation of histone 1 isotype 4 at lysine 26

Mechanistic and structural studies of KDM‐catalysed demethylation of histone 1 isotype 4 at lysine 26

N‐Methylation of lysyl residues is widely observed on histone proteins. Using isolated enzymes, we report mechanistic and structural studies on histone lysine demethylase (KDM)‐catalysed demethylation of Nε‐methylated lysine 26 on histone 1 isotype 4 (H1.4). The results reveal that methylated H1.4K2...

书目详细资料
Main Authors:	Walport, L, Hopkinson, R, Chowdhury, R, Zhang, Y, Bonnici, J, Schiller, R, Kawamura, A, Schofield, C
格式:	Journal article
出版:	Wiley 2018

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