Estimation of systemic complement C3 activity in age-related macular degeneration.
OBJECTIVES: To determine the role of systemic complement activation in the pathogenesis of age-related macular degeneration and to examine whether serum C3a des Arg reflects systemic complement activation, independent of individual complement component levels. METHODS: Plasma complement C3a des Arg...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
2007
|
| _version_ | 1826285048967462912 |
|---|---|
| author | Sivaprasad, S Adewoyin, T Bailey, T Dandekar, S Jenkins, S Webster, A Chong, N |
| author_facet | Sivaprasad, S Adewoyin, T Bailey, T Dandekar, S Jenkins, S Webster, A Chong, N |
| author_sort | Sivaprasad, S |
| collection | OXFORD |
| description | OBJECTIVES: To determine the role of systemic complement activation in the pathogenesis of age-related macular degeneration and to examine whether serum C3a des Arg reflects systemic complement activation, independent of individual complement component levels. METHODS: Plasma complement C3a des Arg levels and a single nucleotide polymorphism at position 402 of the complement factor H gene (CFH) were determined in 3 groups of subjects: 42 subjects with early age-related maculopathy, 42 subjects with neovascular (wet) age-related macular degeneration, and a control group of 38 subjects with no clinical evidence of age-related changes at the macula. RESULTS: The median (range) of plasma complement C3a des Arg levels in the age-related maculopathy and neovascular age-related macular degeneration groups were 52.6 (2.8-198.1) ng/mL and 60.9 (3.1-173.1) ng/mL, respectively. The levels were significantly raised compared with the control group (n = 38), which had a median (range) plasma complement C3a des Arg level of 40.3 (6.1-81.7) ng/mL (analysis of variance, P = .02). The concentration of plasma C3a des Arg did not differ significantly between those with different CFH genotypes (P = .07). CONCLUSION: Systemic activation of the complement system may contribute to the pathogenesis of age-related macular degeneration independent of CFH polymorphism. CLINICAL RELEVANCE: The results of this study may be relevant to aiming new treatment strategies toward reducing systemic low-grade inflammation. |
| first_indexed | 2024-03-07T01:23:01Z |
| format | Journal article |
| id | oxford-uuid:91020e2b-8168-43a2-b30b-878d76834452 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T01:23:01Z |
| publishDate | 2007 |
| record_format | dspace |
| spelling | oxford-uuid:91020e2b-8168-43a2-b30b-878d768344522022-03-26T23:15:38ZEstimation of systemic complement C3 activity in age-related macular degeneration.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:91020e2b-8168-43a2-b30b-878d76834452EnglishSymplectic Elements at Oxford2007Sivaprasad, SAdewoyin, TBailey, TDandekar, SJenkins, SWebster, AChong, N OBJECTIVES: To determine the role of systemic complement activation in the pathogenesis of age-related macular degeneration and to examine whether serum C3a des Arg reflects systemic complement activation, independent of individual complement component levels. METHODS: Plasma complement C3a des Arg levels and a single nucleotide polymorphism at position 402 of the complement factor H gene (CFH) were determined in 3 groups of subjects: 42 subjects with early age-related maculopathy, 42 subjects with neovascular (wet) age-related macular degeneration, and a control group of 38 subjects with no clinical evidence of age-related changes at the macula. RESULTS: The median (range) of plasma complement C3a des Arg levels in the age-related maculopathy and neovascular age-related macular degeneration groups were 52.6 (2.8-198.1) ng/mL and 60.9 (3.1-173.1) ng/mL, respectively. The levels were significantly raised compared with the control group (n = 38), which had a median (range) plasma complement C3a des Arg level of 40.3 (6.1-81.7) ng/mL (analysis of variance, P = .02). The concentration of plasma C3a des Arg did not differ significantly between those with different CFH genotypes (P = .07). CONCLUSION: Systemic activation of the complement system may contribute to the pathogenesis of age-related macular degeneration independent of CFH polymorphism. CLINICAL RELEVANCE: The results of this study may be relevant to aiming new treatment strategies toward reducing systemic low-grade inflammation. |
| spellingShingle | Sivaprasad, S Adewoyin, T Bailey, T Dandekar, S Jenkins, S Webster, A Chong, N Estimation of systemic complement C3 activity in age-related macular degeneration. |
| title | Estimation of systemic complement C3 activity in age-related macular degeneration. |
| title_full | Estimation of systemic complement C3 activity in age-related macular degeneration. |
| title_fullStr | Estimation of systemic complement C3 activity in age-related macular degeneration. |
| title_full_unstemmed | Estimation of systemic complement C3 activity in age-related macular degeneration. |
| title_short | Estimation of systemic complement C3 activity in age-related macular degeneration. |
| title_sort | estimation of systemic complement c3 activity in age related macular degeneration |
| work_keys_str_mv | AT sivaprasads estimationofsystemiccomplementc3activityinagerelatedmaculardegeneration AT adewoyint estimationofsystemiccomplementc3activityinagerelatedmaculardegeneration AT baileyt estimationofsystemiccomplementc3activityinagerelatedmaculardegeneration AT dandekars estimationofsystemiccomplementc3activityinagerelatedmaculardegeneration AT jenkinss estimationofsystemiccomplementc3activityinagerelatedmaculardegeneration AT webstera estimationofsystemiccomplementc3activityinagerelatedmaculardegeneration AT chongn estimationofsystemiccomplementc3activityinagerelatedmaculardegeneration |