Cryo-EM structures of perforin-2 in isolation and assembled on a membrane suggest a mechanism for pore formation

<p>Perforin-2 (PFN2, MPEG1) is a key pore-forming protein in mammalian innate immunity restricting intracellular bacteria proliferation. It forms a membrane-bound pre-pore complex that converts to a pore-forming structure upon acidification; but its mechanism of conformational transition has b...

Бүрэн тодорхойлолт

Номзүйн дэлгэрэнгүй
Үндсэн зохиолчид: Yu, X, Ni, T, Munson, G, Zhang, P, Gilbert, RJC
Формат: Journal article
Хэл сонгох:English
Хэвлэсэн: EMBO Press 2022