MDMX acts as a pervasive preleukemic-to-acute myeloid leukemia transition mechanism

MDMX acts as a pervasive preleukemic-to-acute myeloid leukemia transition mechanism

MDMX is overexpressed in the vast majority of patients with acute myeloid leukemia (AML). We report that MDMX overexpression increases preleukemic stem cell (pre-LSC) number and competitive advantage. Utilizing five newly generated murine models, we found that MDMX overexpression triggers progressio...

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Bibliographic Details
Main Authors: Ueda, K, Kumari, R, Schwenger, E, Wheat, JC, Bohorquez, O, Narayanagari, S-R, Taylor, SJ, Carvajal, LA, Pradhan, K, Bartholdy, B, Todorova, TI, Goto, H, Sun, D, Chen, J, Shan, J, Song, Y, Montagna, C, Xiong, S, Lozano, G, Pellagatti, A, Boultwood, J, Verma, A, Steidl, U
Format: Journal article
Language:English
Published: Cell Press 2021

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