HLA correlates in a cohort of slow progressors from China: effects on HIV-1 disease progression.
We looked at our HIV + slow progressors cohort to determine if there were any human leukocyte antigen (HLA) correlates for protection. No statistically significant allelic differences were found between the HIV + and control cohorts using regression analysis, though trends were noted. Data for Elite...
| मुख्य लेखकों: | , , , , , , , , , , , , , |
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| स्वरूप: | Journal article |
| भाषा: | English |
| प्रकाशित: |
2013
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| _version_ | 1826285119298600960 |
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| author | Rai, M Zhang, Y Yindom, L Holmes, J Yu, L Hao, C Rostron, T Yan, H Zhang, Y Cai, C Mcmichael, A Dong, T Rowland-Jones, S Blais, M Xu, K |
| author_facet | Rai, M Zhang, Y Yindom, L Holmes, J Yu, L Hao, C Rostron, T Yan, H Zhang, Y Cai, C Mcmichael, A Dong, T Rowland-Jones, S Blais, M Xu, K |
| author_sort | Rai, M |
| collection | OXFORD |
| description | We looked at our HIV + slow progressors cohort to determine if there were any human leukocyte antigen (HLA) correlates for protection. No statistically significant allelic differences were found between the HIV + and control cohorts using regression analysis, though trends were noted. Data for Elite Controllers showed an increased frequency of B*57. Likewise, no correlation was inferred with the clinical data of the HIV + cohort. We hypothesize that the protective effect of HLA alleles may have been lost over time. |
| first_indexed | 2024-03-07T01:24:05Z |
| format | Journal article |
| id | oxford-uuid:915b5b51-5460-4519-8953-effc9058d4f4 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T01:24:05Z |
| publishDate | 2013 |
| record_format | dspace |
| spelling | oxford-uuid:915b5b51-5460-4519-8953-effc9058d4f42022-03-26T23:18:19ZHLA correlates in a cohort of slow progressors from China: effects on HIV-1 disease progression.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:915b5b51-5460-4519-8953-effc9058d4f4EnglishSymplectic Elements at Oxford2013Rai, MZhang, YYindom, LHolmes, JYu, LHao, CRostron, TYan, HZhang, YCai, CMcmichael, ADong, TRowland-Jones, SBlais, MXu, KWe looked at our HIV + slow progressors cohort to determine if there were any human leukocyte antigen (HLA) correlates for protection. No statistically significant allelic differences were found between the HIV + and control cohorts using regression analysis, though trends were noted. Data for Elite Controllers showed an increased frequency of B*57. Likewise, no correlation was inferred with the clinical data of the HIV + cohort. We hypothesize that the protective effect of HLA alleles may have been lost over time. |
| spellingShingle | Rai, M Zhang, Y Yindom, L Holmes, J Yu, L Hao, C Rostron, T Yan, H Zhang, Y Cai, C Mcmichael, A Dong, T Rowland-Jones, S Blais, M Xu, K HLA correlates in a cohort of slow progressors from China: effects on HIV-1 disease progression. |
| title | HLA correlates in a cohort of slow progressors from China: effects on HIV-1 disease progression. |
| title_full | HLA correlates in a cohort of slow progressors from China: effects on HIV-1 disease progression. |
| title_fullStr | HLA correlates in a cohort of slow progressors from China: effects on HIV-1 disease progression. |
| title_full_unstemmed | HLA correlates in a cohort of slow progressors from China: effects on HIV-1 disease progression. |
| title_short | HLA correlates in a cohort of slow progressors from China: effects on HIV-1 disease progression. |
| title_sort | hla correlates in a cohort of slow progressors from china effects on hiv 1 disease progression |
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