The effect of different etiologies of hepatic impairment on the pharmacokinetics of gefitinib.

PURPOSE: We investigated whether the pharmacokinetics and tolerability of gefitinib were altered in patients with hepatic impairment due to cirrhosis or hepatic metastases in two open, parallel-group, multicenter studies. METHODS: In Study 1, subjects with normal hepatic function or mild, moderate,...

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Príomhchruthaitheoirí: Horak, J, White, J, Harris, A, Verrill, M, Carmichael, J, Holt, A, Cantarini, M, Macpherson, M, Swaisland, A, Swaisland, H, Twelves, C
Formáid: Journal article
Teanga:English
Foilsithe / Cruthaithe: 2011