Inhibition of mitochondrial aconitase by succination in fumarate hydratase deficiency.

Inhibition of mitochondrial aconitase by succination in fumarate hydratase deficiency.

अन्य संस्करण दिखाएं (1)

The gene encoding the Krebs cycle enzyme fumarate hydratase (FH) is mutated in hereditary leiomyomatosis and renal cell cancer (HLRCC). Loss of FH activity causes accumulation of intracellular fumarate, which can directly modify cysteine residues to form 2-succinocysteine through succination. We und...

पूर्ण विवरण

ग्रंथसूची विवरण
मुख्य लेखकों:	Ternette, N, Yang, M, Laroyia, M, Kitagawa, M, O'Flaherty, L, Wolhulter, K, Igarashi, K, Saito, K, Kato, K, Fischer, R, Berquand, A, Kessler, B, Lappin, T, Frizzell, N, Soga, T, Adam, J, Pollard, P
स्वरूप:	Journal article
भाषा:	English
प्रकाशित:	2013

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