Inhibition of mitochondrial aconitase by succination in fumarate hydratase deficiency.

The gene encoding the Krebs cycle enzyme fumarate hydratase (FH) is mutated in hereditary leiomyomatosis and renal cell cancer (HLRCC). Loss of FH activity causes accumulation of intracellular fumarate, which can directly modify cysteine residues to form 2-succinocysteine through succination. We und...

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Main Authors:	Ternette, N, Yang, M, Laroyia, M, Kitagawa, M, O'Flaherty, L, Wolhulter, K, Igarashi, K, Saito, K, Kato, K, Fischer, R, Berquand, A, Kessler, B, Lappin, T, Frizzell, N, Soga, T, Adam, J, Pollard, P
Format:	Journal article
Language:	English
Published:	2013

Inhibition of Mitochondrial Aconitase by Succination in Fumarate Hydratase Deficiency by Ternette, N, Fischer, R, Kessler, B, Yang, M, Laroyia, M, O'Flaherty, L, Wolhulter, K, Adam, J, Pollard, P, Lappin, T, Kitagawa, M, Igarashi, K, Saito, K, Kato, K, Soga, T, Berquand, A, Frizzell, N

Published 2013

Journal article

Inhibition of mitochondrial aconitase by succination in fumarate hydratase deficiency.

Inhibition of Mitochondrial Aconitase by Succination in Fumarate Hydratase Deficiency by Ternette, N, Fischer, R, Kessler, B, Yang, M, Laroyia, M, O'Flaherty, L, Wolhulter, K, Adam, J, Pollard, P, Lappin, T, Kitagawa, M, Igarashi, K, Saito, K, Kato, K, Soga, T, Berquand, A, Frizzell, N

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