Recognition of phosphodegron motifs in human cyclin E by the SCF(Fbw7) ubiquitin ligase.

Recognition of phosphodegron motifs in human cyclin E by the SCF(Fbw7) ubiquitin ligase.

Turnover of cyclin E is controlled by SCF(Fbw7). Three isoforms of Fbw7 are produced by alternative splicing. Whereas Fbw7alpha and -gamma are nuclear and the beta-isoform is cytoplasmic in 293T cells, all three isoforms induce cyclin E destruction in an in vivo degradation assay. Cyclin E is phosph...

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Bibliographic Details
Main Authors:	Ye, X, Nalepa, G, Welcker, M, Kessler, B, Spooner, E, Qin, J, Elledge, S, Clurman, B, Harper, J
Format:	Journal article
Language:	English
Published:	2004

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