SPFH1 and SPFH2 mediate the ubiquitination and degradation of inositol 1,4,5-trisphosphate receptors in muscarinic receptor-expressing HeLa cells.

SPFH1 and SPFH2 mediate the ubiquitination and degradation of inositol 1,4,5-trisphosphate receptors in muscarinic receptor-expressing HeLa cells.

Inositol 1,4,5-trisphosphate (IP(3)) receptors are endoplasmic reticulum (ER) membrane calcium channels that, upon activation, become substrates for the ER-associated degradation (ERAD) pathway. While it is clear that IP(3) receptors are polyubiquitinated and are transferred to the proteasome by a p...

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Bibliographic Details
Main Authors:	Wang, Y, Pearce, M, Sliter, D, Olzmann, J, Christianson, J, Kopito, R, Boeckmann, S, Gagen, C, Leichner, G, Roitelman, J, Wojcikiewicz, R
Format:	Journal article
Language:	English
Published:	2009

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