Mechanism for a directional, processive, and reversible DNA motor.
A bipedal motor mechanism that coordinates the chemical and mechanical cycles of two-identical feet can be generalized to obtain energy from hydrolysis of a DNA or RNA fuel was demonstrated. The motors that can operate continuously on a reusable track require a separate fuel, linear motion and can b...
| Main Authors: | , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Wiley
2009
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| _version_ | 1797082185003433984 |
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| author | Bath, J Green, S Allen, K Turberfield, A |
| author_facet | Bath, J Green, S Allen, K Turberfield, A |
| author_sort | Bath, J |
| collection | OXFORD |
| description | A bipedal motor mechanism that coordinates the chemical and mechanical cycles of two-identical feet can be generalized to obtain energy from hydrolysis of a DNA or RNA fuel was demonstrated. The motors that can operate continuously on a reusable track require a separate fuel, linear motion and can be coupled to ATP hydrolysis by using a motor architecture. The interaction between fuel and motor can be followed by labeling a fuel at the 5 inches end with FAM and at the 3 inches with TAMRA, thereby decreasing the fluorescence resonance energy transfer (FRET). The mechanism derived has the properties required to create a chemically fueled molecular motor that is both directional and processive, and the directional bias of these motors can be reversed by changing the fuel. |
| first_indexed | 2024-03-07T01:24:37Z |
| format | Journal article |
| id | oxford-uuid:918ae7e0-685e-43d8-b167-c714e3674287 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T01:24:37Z |
| publishDate | 2009 |
| publisher | Wiley |
| record_format | dspace |
| spelling | oxford-uuid:918ae7e0-685e-43d8-b167-c714e36742872022-03-26T23:19:26ZMechanism for a directional, processive, and reversible DNA motor.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:918ae7e0-685e-43d8-b167-c714e3674287EnglishSymplectic Elements at OxfordWiley2009Bath, JGreen, SAllen, KTurberfield, AA bipedal motor mechanism that coordinates the chemical and mechanical cycles of two-identical feet can be generalized to obtain energy from hydrolysis of a DNA or RNA fuel was demonstrated. The motors that can operate continuously on a reusable track require a separate fuel, linear motion and can be coupled to ATP hydrolysis by using a motor architecture. The interaction between fuel and motor can be followed by labeling a fuel at the 5 inches end with FAM and at the 3 inches with TAMRA, thereby decreasing the fluorescence resonance energy transfer (FRET). The mechanism derived has the properties required to create a chemically fueled molecular motor that is both directional and processive, and the directional bias of these motors can be reversed by changing the fuel. |
| spellingShingle | Bath, J Green, S Allen, K Turberfield, A Mechanism for a directional, processive, and reversible DNA motor. |
| title | Mechanism for a directional, processive, and reversible DNA motor. |
| title_full | Mechanism for a directional, processive, and reversible DNA motor. |
| title_fullStr | Mechanism for a directional, processive, and reversible DNA motor. |
| title_full_unstemmed | Mechanism for a directional, processive, and reversible DNA motor. |
| title_short | Mechanism for a directional, processive, and reversible DNA motor. |
| title_sort | mechanism for a directional processive and reversible dna motor |
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