The directed growth of retinal axons towards surgically transposed tecta in Xenopus; an examination of homing behaviour by retinal ganglion cell axons.
The growth of optic axons towards experimentally rotated tecta has been studied. In stage 24/25 embryos, a piece of the dorsal neural tube, containing the dorsal midbrain rudiment, was rotated through 180 degrees. At later stages of development, the pathways of growing optic axons were investigated...
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| Format: | Journal article |
| Language: | English |
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1990
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| _version_ | 1797082185406087168 |
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| author | Taylor, J |
| author_facet | Taylor, J |
| author_sort | Taylor, J |
| collection | OXFORD |
| description | The growth of optic axons towards experimentally rotated tecta has been studied. In stage 24/25 embryos, a piece of the dorsal neural tube, containing the dorsal midbrain rudiment, was rotated through 180 degrees. At later stages of development, the pathways of growing optic axons were investigated by labelling with either horseradish peroxidase or fluorescent dye. It is shown that retinal ganglion cell axons followed well-defined pathways, in spite of the abnormal structure of the brain, and were able to locate displaced tecta. This directed outgrowth of retinal axons in the optic tracts appears to be related either to the tectum or to some other component included in the graft operations. In tadpoles in which the midbrain rudiment was removed, optic axons still followed the normal course of the optic tract. This observation argues against long-range target attraction as being essential in guiding growing retinal axons towards the tectum. An alternative axon guidance mechanism, selective fasciculation, is discussed as a possible alternative to explain the directed axon outgrowth which occurs in both the normal and in these experimentally manipulated tadpoles. |
| first_indexed | 2024-03-07T01:24:37Z |
| format | Journal article |
| id | oxford-uuid:918b4ca9-f5c8-4db1-abec-c4c7cd87ac21 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T01:24:37Z |
| publishDate | 1990 |
| record_format | dspace |
| spelling | oxford-uuid:918b4ca9-f5c8-4db1-abec-c4c7cd87ac212022-03-26T23:19:26ZThe directed growth of retinal axons towards surgically transposed tecta in Xenopus; an examination of homing behaviour by retinal ganglion cell axons.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:918b4ca9-f5c8-4db1-abec-c4c7cd87ac21EnglishSymplectic Elements at Oxford1990Taylor, JThe growth of optic axons towards experimentally rotated tecta has been studied. In stage 24/25 embryos, a piece of the dorsal neural tube, containing the dorsal midbrain rudiment, was rotated through 180 degrees. At later stages of development, the pathways of growing optic axons were investigated by labelling with either horseradish peroxidase or fluorescent dye. It is shown that retinal ganglion cell axons followed well-defined pathways, in spite of the abnormal structure of the brain, and were able to locate displaced tecta. This directed outgrowth of retinal axons in the optic tracts appears to be related either to the tectum or to some other component included in the graft operations. In tadpoles in which the midbrain rudiment was removed, optic axons still followed the normal course of the optic tract. This observation argues against long-range target attraction as being essential in guiding growing retinal axons towards the tectum. An alternative axon guidance mechanism, selective fasciculation, is discussed as a possible alternative to explain the directed axon outgrowth which occurs in both the normal and in these experimentally manipulated tadpoles. |
| spellingShingle | Taylor, J The directed growth of retinal axons towards surgically transposed tecta in Xenopus; an examination of homing behaviour by retinal ganglion cell axons. |
| title | The directed growth of retinal axons towards surgically transposed tecta in Xenopus; an examination of homing behaviour by retinal ganglion cell axons. |
| title_full | The directed growth of retinal axons towards surgically transposed tecta in Xenopus; an examination of homing behaviour by retinal ganglion cell axons. |
| title_fullStr | The directed growth of retinal axons towards surgically transposed tecta in Xenopus; an examination of homing behaviour by retinal ganglion cell axons. |
| title_full_unstemmed | The directed growth of retinal axons towards surgically transposed tecta in Xenopus; an examination of homing behaviour by retinal ganglion cell axons. |
| title_short | The directed growth of retinal axons towards surgically transposed tecta in Xenopus; an examination of homing behaviour by retinal ganglion cell axons. |
| title_sort | directed growth of retinal axons towards surgically transposed tecta in xenopus an examination of homing behaviour by retinal ganglion cell axons |
| work_keys_str_mv | AT taylorj thedirectedgrowthofretinalaxonstowardssurgicallytransposedtectainxenopusanexaminationofhomingbehaviourbyretinalganglioncellaxons AT taylorj directedgrowthofretinalaxonstowardssurgicallytransposedtectainxenopusanexaminationofhomingbehaviourbyretinalganglioncellaxons |