PET imaging of DNA damage using (89)Zr-labelled anti-γH2AX-TAT immunoconjugates.
PURPOSE: The efficacy of most anticancer treatments, including radiotherapy, depends on an ability to cause DNA double-strand breaks (DSBs). Very early during the DNA damage signalling process, the histone isoform H2AX is phosphorylated to form γH2AX. With the aim of positron emission tomography (PE...
| Principais autores: | , , , , , , |
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| Formato: | Journal article |
| Idioma: | English |
| Publicado em: |
Springer Berlin Heidelberg
2015
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